< 生产厂家价格 >

氯化锦葵色素-3-O-半乳糖苷

氯化锦葵色素-3-O-半乳糖苷用途

Malvidin-3-半乳糖苷氯化物是一种花青素色素，存在于报红和暗红色的报春花中。

点击显示

氯化锦葵色素-3-O-半乳糖苷名称

[ CAS 号 ]:
30113-37-2

[ 中文名 ]:
氯化锦葵色素-3-半乳糖苷

[ 英文名 ]:
Malvidin-3-O-galactoside chloride

[中文别名 ]:

[英文别名 ]:

PRIMULINE FOR MICROSCOPY
PRIMULIN
PRIMULIN CHLORIDE
EINECS 250-055-1
MALVIDIN-3-O-GALACTOSIDE CHLORIDE
malvidin 3-galactoside

氯化锦葵色素-3-O-半乳糖苷生物活性

[ 描述 ]:

Malvidin-3-氯化半乳糖苷是一种花青素单体,可诱导肝细胞癌(HCC)细胞周期阻滞和凋亡。Malvidin-3-半乳糖苷氯化物抑制活性氧的产生和积累。Malvidin-3-半乳糖苷氯化物具有抗肿瘤功能[1]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> 蛋白酪氨酸激酶 >> ROS

[体外研究]

Malvidin-3-半乳糖苷氯化物(50,100,200μg/mL；24、48、72h)对Huh-7细胞有明显的细胞毒性,50和100μg/mL对48h无明显影响。Malvidin-3-半乳糖苷氯化物在72小时时对Huh-7细胞具有显著的细胞毒性作用[1]。Malvidin-3-氯化半乳糖苷(50-200μg/mL)阻止S期细胞,伴随着G1期细胞减少,S期细胞增加[1]。Malvidin-3-氯化半乳糖苷(50-200μg/mL；72小时)诱导Huh-7细胞凋亡[1]。Malvidin-3-氯化半乳糖苷(50-200μg/mL；72小时)以剂量依赖性方式显著增加半胱氨酸蛋白酶-3、裂解半胱氨酸蛋白酶-3和裂解PARP的水平[1]。Malvidin-3-氯化半乳糖苷(50-200μg/mL；12小时)抑制活性氧的产生和积累[1]。Malvidin-3-氯化半乳糖苷(50-200μg/mL；12小时)以剂量依赖性方式显著降低磷酸化ERK(p-ERK)水平。200μg/mL的Malvidin-3-半乳糖苷氯化物显著增加p38和JNK(p-p38和p-JNK)[1]的磷酸化水平。Malvidin-3-氯化半乳糖苷(50-200μg/mL；12小时)抑制Huh-7细胞的迁移和侵袭[1]。

[参考文献]

[1]. Jie Lin, et al. Malvidin-3-galactoside from blueberry suppresses the growth and metastasis potential of hepatocellular carcinoma cell Huh-7 by regulating apoptosis and metastases pathways. Food Science and Human Wellness, Volume 9, Issue 2, June 2020, Pages 136-145.

氯化锦葵色素-3-O-半乳糖苷物理化学性质

[ 分子式 ]:
C₂₃H₂₅ClO₁₂

[ 分子量 ]:
528.890

[ 精确质量 ]:
528.103455

[ PSA ]:
191.67000

[ 外观性状 ]:
固体

[ 储存条件 ]:
2-8°C

氯化锦葵色素-3-O-半乳糖苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

氯化锦葵色素-3-O-半乳糖苷文献

Bog bilberry (Vaccinium uliginosum L.) extract reduces cultured Hep-G2, Caco-2, and 3T3-L1 cell viability, affects cell cycle progression, and has variable effects on membrane permeability.

J. Food Sci. 75(3) , H103-7, (2010)

Bog bilberry (Vaccinium uliginosum L.) is a blue-pigmented edible berry related to bilberry (Vaccinium myrtillus L.) and the common blueberry (Vaccinium corymbosum). The objective of this study was to...

Phenolic compounds and bioactivities of pigmented rice.

Crit. Rev. Food Sci. Nutr 53(3) , 296-306, (2013)

The pigmented rice has been consumed in China, Japan, and Korea for a long time. It has been used for strengthening kidney function, treating anemia, promoting blood circulation, removing blood stasis...

Direct effects of Vaccinium myrtillus L. fruit extracts on rat heart mitochondrial functions.

Phytother Res. 27(4) , 499-506, (2013)

In this study, the direct influence of bilberry (Vaccinium myrtillus) fruit extracts (aqueous and ethanolic) rich in anthocyanins on the oxidative phosphorylation of isolated rat heart mitochondria wa...

更多文献