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P7C3

P7C3用途

P7C3是NAMPT激活剂,P7C3能够提高大鼠的学习和记忆能力,能够保护新生神经元减轻细胞死亡。

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P7C3名称

[ CAS 号 ]:
301353-96-8

[ 中文名 ]:
P7C3

[ 英文名 ]:
P7C3

[英文别名 ]:

P7C3

P7C3生物活性

[ 描述 ]:

P7C3是NAMPT激活剂,P7C3能够提高大鼠的学习和记忆能力,能够保护新生神经元减轻细胞死亡。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> NAMPT

研究领域 >> 神经疾病

[参考文献]

[1]. Pieper AA et al. Discovery of a proneurogenic, neuroprotective chemical. Cell. 2010 Jul 9;142(1):39-51.

[2]. Wang G et al. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell. 2014 Sep 11;158(6):1324-34.

[3]. Pieper AA et al. P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases. Chem Soc Rev. 2014 Oct 7;43(19):6716-26.

[相关活性小分子]

(E)-Daporinad | STF-118804 | N-[6-(4-氯苯氧基)己基]-N'-氰基-N''-4-吡啶基胍 | KPT-9274 | N-[[4-[(3,5-二氟苯基)磺酰基]苯基]甲基]咪唑并[1,2-A]吡啶-6-甲酰胺 | 2-羟基-2-甲基-N-[1,2,3,4-四氢-2-[2-(3-吡啶基氧基)乙酰基]-6-异喹啉基]-1-丙烷磺酰胺 | CB 300919 | CB30865

P7C3物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
656.4±55.0 °C at 760 mmHg

[ 分子式 ]:
C₂₁H₁₈Br₂N₂O

[ 分子量 ]:
474.188

[ 闪点 ]:
350.8±31.5 °C

[ 精确质量 ]:
471.978577

[ PSA ]:
37.19000

[ LogP ]:
6.60

[ 外观性状 ]:
white solid

[ 蒸汽压 ]:
0.0±2.1 mmHg at 25°C

[ 折射率 ]:
1.687

[ 储存条件 ]:
-20℃

P7C3MSDS

详细MSDS(安全技术说明书)

P7C3安全信息

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H318

[ 警示性声明 ]:
P280-P301 + P310-P305 + P351 + P338

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ 海关编码 ]:
2933990090

P7C3海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

P7C3文献

Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down Syndrome [Corrected].

Neurosci. Lett. 591 , 86-92, (2015)

Down syndrome (DS) is the most common genetic cause of intellectual disability and developmental delay. In addition to cognitive dysfunction, DS patients are marked by diminished neurogenesis, a neuro...

Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies.

Hum. Mol. Genet. 22(7) , 1432-42, (2013)

Retinal dystrophies are predominantly caused by mutations affecting the visual phototransduction system and cilia, with few genes identified that function to maintain photoreceptor survival. We reason...

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis.

Proc. Natl. Acad. Sci. U. S. A. 109(42) , 17016-21, (2012)

We previously reported the discovery of P7C3, an aminopropyl carbazole having proneurogenic and neuroprotective properties in newborn neural precursor cells of the hippocampal dentate gyrus. We have f...

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