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乳清苷

乳清苷用途

Orotidine 是 DNA 和 RNA 的嘧啶核苷酸合成过程中的一个中间产物,在现代生物中起到重要作用。

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乳清苷名称

[ CAS 号 ]:
314-50-1

[ 中文名 ]:
乳清苷

[ 英文名 ]:
Orotidine

[中文别名 ]:

[英文别名 ]:

UNII:B350MC02GZ
6-Carboxyuridin
Uridine-6-carboxylic acid
3-b-D-Ribofuranosylorotic Acid
Orotidine
Uridine, 6-carboxy-
Orotidine (Uridine-6-carboxylic acid)
6-Carboxyuridine
URIDIN-6-CARBOXYLIC ACID

乳清苷生物活性

[ 描述 ]:

Orotidine 是 DNA 和 RNA 的嘧啶核苷酸合成过程中的一个中间产物,在现代生物中起到重要作用。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Kim EK, et al. Synthesis of orotidine by intramolecular nucleosidation. Chem Commun (Camb). 2015 Apr 4;51(26):5618-21.

[相关活性小分子]

乳清苷物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 熔点 ]:
200ºC

[ 分子式 ]:
C₁₀H₁₂N₂O₈

[ 分子量 ]:
288.211

[ 精确质量 ]:
288.059357

[ PSA ]:
162.08000

[ LogP ]:
-1.24

[ 折射率 ]:
1.678

乳清苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934999090

乳清苷海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

乳清苷文献

Pyrophosphate interactions at the transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases.

J. Am. Chem. Soc. 132(25) , 8787-94, (2010)

Orotate phosphoribosyltransferases from Plasmodium falciparum and human sources (PfOPRT and HsOPRT) use orotidine as a slow substrate in the pyrophosphorolysis reaction. With orotidine, intrinsic kine...

The allopurinol load test lacks specificity for primary urea cycle defects but may indicate unrecognized mitochondrial disease.

J. Inherit. Metab. Dis. 22(2) , 174-84, (1999)

Thirty-three children ranging from 2 weeks to 12 years of age were selected for allopurinol loading, 16 on the basis of an increased urinary ourotate excretion detected by routine organic acid analysi...

Orotidine accumulation in human erythrocytes during allopurinol therapy: association with high urinary oxypurinol-7-riboside concentrations in renal failure and in the Lesch-Nyhan syndrome.

Clin. Sci. 80(3) , 191-7, (1991)

1. A compound identified as orotidine has been found in the erythrocytes of all subjects on allopurinol. 2. The erythrocyte orotidine concentrations were much higher in patients with renal failure or ...

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乳清苷