安西他滨
安西他滨用途
Ancitabine 是一类抗白血病活性分子。
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安西他滨名称
[ CAS 号 ]:
31698-14-3
[ 中文名 ]:
安西他滨
[ 英文名 ]:
Ancitabine
[中文别名 ]:
[英文别名 ]:
- anhydroarac
- CYCLOCYTIDINE HCL
- Cyclocytidine
- Ancitabine
- 2,2'-ANHYDRO-L-CYTIDINE
- 2,2'-anhydrocytidine
- anhydrocytidine
- cyclocitidine
- ancytabine
安西他滨生物活性
安西他滨物理化学性质
[ 密度 ]:
2.01 g/cm3
[ 沸点 ]:
422.2ºCat 760 mmHg
[ 熔点 ]:
269-270ºC
[ 分子式 ]:
C9H11N3O4
[ 分子量 ]:
225.20100
[ 精确质量 ]:
225.07500
[ PSA ]:
100.59000
[ 折射率 ]:
1.5100 (estimate)
[ 储存条件 ]:
−20°C
安西他滨毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LV2610000
- CAS REGISTRY NUMBER :
- 31698-14-3
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C9-H11-N3-O4
- MOLECULAR WEIGHT :
- 225.23
- WISWESSER LINE NOTATION :
- T B556 AN CO GO INYTT&J D1Q EQ JUM
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >7 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1700 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 820 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3400 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1600 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4050 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2745 mg/kg/9W-I
- TOXIC EFFECTS :
- Endocrine - changes in adrenal weight Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Leukocyte
- DOSE/DURATION :
- 700 ug/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 23,1235,1974
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安西他滨安全信息
[ WGK德国 ]:
2
[ RTECS号 ]:
LV2615000
安西他滨合成路线
安西他滨上下游产品
安西他滨上游产品
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