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酒石酸噻吩嘧啶

酒石酸噻吩嘧啶用途

Pyrantel酒石酸盐是一种驱线虫噻吩；烟碱受体激动剂。

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酒石酸噻吩嘧啶名称

[ CAS 号 ]:
33401-94-4

[ 中文名 ]:
酒石酸噻吩嘧啶

[ 英文名 ]:
Pyrantel tartrate

[中文别名 ]:

噻嘧啶酒石酸

[英文别名 ]:

Pyrantel tartrate
Pyranteltartrat
Pyrantel (+)-tartrate salt
Pyrantel Tartate
pyrantel hydrogen tartrate
Pyrantel (tartrate)

酒石酸噻吩嘧啶生物活性

[ 描述 ]:

Pyrantel酒石酸盐是一种驱线虫噻吩；烟碱受体激动剂。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[参考文献]

[1]. Aceves J, et al. The mechanism of the paralysing action of tetramisole on Ascaris somatic muscle. Br J Pharmacol. 1970 May;38(3):602-7.

[2]. Aubry ML, et al. Aspects of the pharmacology of a new anthelmintic: pyrantel. Br J Pharmacol. 1970 Feb;38(2):332-44.

[相关活性小分子]

酒石酸噻吩嘧啶物理化学性质

[ 沸点 ]:
324.4ºC at 760 mmHg

[ 熔点 ]:
148-150ºC

[ 分子式 ]:
C₁₅H₂₀N₂O₆S

[ 分子量 ]:
356.39400

[ 闪点 ]:
150ºC

[ 精确质量 ]:
356.10400

[ PSA ]:
158.90000

[ 外观性状 ]:
白色晶体

[ 储存条件 ]:
2-8℃

[ 水溶解性 ]:
H2O: soluble4.0ML, clear, colorless to faint yellow or tan (Solvent: 200 mg plus 4.0 mL )

酒石酸噻吩嘧啶MSDS

详细MSDS(安全技术说明书)

酒石酸噻吩嘧啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UW0249000

CAS REGISTRY NUMBER :: 33401-94-4

LAST UPDATED :: 199706

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C11-H14-N2-S.C4-H6-O6

MOLECULAR WEIGHT :: 356.43

WISWESSER LINE NOTATION :: T6N CN AUTJ B1U1- BT5SJ& C1 &QVYQYQVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AUVJA2 Australian Veterinary Journal. (Australian Veterinary Assoc., Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2- 1927- Volume(issue)/page/year: 46,297,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 123 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,305,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,305,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2220 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,305,1971

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cattle

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AUVJA2 Australian Veterinary Journal. (Australian Veterinary Assoc., Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2- 1927- Volume(issue)/page/year: 46,297,1970 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 6750 mg/kg/90D-I

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from large intestine Gastrointestinal - other changes

REFERENCE :: AUVJA2 Australian Veterinary Journal. (Australian Veterinary Assoc., Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2- 1927- Volume(issue)/page/year: 46,297,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9280 No. of Facilities: 498 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 3688 (estimated)

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酒石酸噻吩嘧啶安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
UW0249000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

酒石酸噻吩嘧啶文献

Evaluation of pyrantel-tartrate abbreviated Ascaris suum infections for the development of resistance in young pigs against migrating larvae.

Int. J. Parasitol. 20(1) , 77-81, (1990)

Crossbred young pigs were used to test whether abbreviated infections with eggs of Ascaris suum can stimulate the acquisition of resistance to challenge. Weanling pigs from an Ascaris-free colony were...

Concurrent infections with the ruminant nematodes Haemonchus contortus and Trichostrongylus colubriformis in jirds, Meriones unguiculatus, and use of this model for anthelmintic studies.

J. Parasitol. 77(4) , 621-3, (1991)

Haemonchus contortus- and Trichostrongylus colubriformis-infected jirds (Meriones unguiculatus) are useful for anthelmintic studies. With concurrent infections of these parasites established in the ji...

Pyrantel pamoate resistance in horses receiving daily administration of pyrantel tartrate.

J. Am. Vet. Med. Assoc. 228(1) , 101-3, (2006)

16 horses treated daily with pyrantel tartrate (2.64 mg/kg [1.2 mg/lb], PO) as part of a prophylactic anthelmintic program.Fecal worm egg counts (FWECs) were obtained on all 16 horses. Mean FWEC was 4...

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