萘啶酸钠盐

萘啶酸钠盐用途

Nalidixic acid sodium salt,一种喹诺酮类抗生素 (antibiotic),对革兰氏阳性和革兰氏阴性细菌均有效。Nalidixic acid sodium salt 在较低浓度下以抑菌的方式起作用,而在较高浓度下具有杀菌作用。Nalidixic acid sodium salt 抑制 DNA 促旋酶和拓扑异构酶IV的亚基,并可逆地阻止易感细菌中的 DNA 复制。

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萘啶酸钠盐名称

[ CAS 号 ]:
3374-05-8

[ 中文名 ]:
萘啶酮酸钠

[ 英文名 ]:
Nalidixic acid sodium salt

[中文别名 ]:

[英文别名 ]:

nalidixic acid sodium
sodiumnalidixate
EINECS 222-159-7
MFCD00064376
sodium nalidixicate
sodiumnilixalate
nalidixic acid sodium salt
nalidixic acid,sodium salt
nalidixatesodium

萘啶酸钠盐生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[ 靶点 ]

Topoisomerase

[体外研究]

萘啶酸对多种微生物有拮抗作用,对大肠杆菌、巴氏杆菌、肺炎克雷伯菌、需氧菌、变形杆菌、沙门氏菌、志贺氏菌、布鲁氏菌的MIC值为5.0-12.5μg/ml、0.5-2.5μg/ml、0.8-25.0μg/ml、1.0-25.0μg/ml、1.25-30.0μg/ml、8-3.2μg/ml,分别为7.5-10.0μg/ml[1]。

[体内研究]

萘啶酸对革兰氏阴性菌的体内活性最为显著,而革兰氏阳性菌通常更具抗药性。对大肠杆菌、产气杆菌、奇异变形杆菌、fkxneri志贺氏菌引起的全身感染具有最大活性,ED50值分别为25 mg/kg、60 mg/kg、50 mg/kg和62 mg/kg[1]。口服和肠外给药后,萘啶酸对小鼠的急性毒性(LD50)为：口服3300 mg/kg；静脉注射176 mg/kg；皮下500 mg/kg[1]。

[参考文献]

[1]. G Y LESHER,et al. 1,8-NAPHTHYRIDINE DERIVATIVES. A NEW CLASS OF CHEMOTHERAPEUTIC AGENTS. J Med Pharm Chem. 1962 Sep;91:1063-5.

[2]. Anna Fàbrega, et al. Mechanism of Action of and Resistance to Quinolones. Microb Biotechnol

萘啶酸钠盐物理化学性质

[ 密度 ]:
1.331g/cm3

[ 沸点 ]:
413.1ºC at 760mmHg

[ 熔点 ]:
229-230ºC

[ 分子式 ]:
C₁₂H₁₁N₂NaO₃

[ 分子量 ]:
254.21700

[ 闪点 ]:
203.6ºC

[ 精确质量 ]:
254.06700

[ PSA ]:
75.02000

[ LogP ]:
0.08830

[ 外观性状 ]:
白色至灰白色粉末

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: 50 mg/mL, clear, faintly yellow

萘啶酸钠盐MSDS

详细MSDS(安全技术说明书)

萘啶酸钠盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QN2885500

CHEMICAL NAME :: 1,8-Naphthyridine-3-carboxylic acid, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-, sodium salt

CAS REGISTRY NUMBER :: 3374-05-8

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H12-N2-O3.Na

MOLECULAR WEIGHT :: 255.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Cells - not otherwise specified

DOSE/DURATION :: 900 mg/L

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 60,287,1987

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萘啶酸钠盐安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H317-H334

[ 警示性声明 ]:
P261-P280-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R42/43

[ 安全声明 (欧洲) ]:
S22-S36/37-S45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
-

[ RTECS号 ]:
QN2885500

[ 海关编码 ]:
2933990090

萘啶酸钠盐海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

萘啶酸钠盐文献

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Differential regulation of OmpC and OmpF by AtpB in Escherichia coli exposed to nalidixic acid and chlortetracycline.

J. Proteomics 75(18) , 5898-910, (2012)

Little is known about mechanisms through which OmpR/EnvZ and CpxA/CpxR regulate the expression of OmpC and OmpF, and thereby regulate bacterial responses to antibiotics exposure. In this study we inve...

Antibiotic susceptibility profile of Aeromonas species isolated from wastewater treatment plant.

ScientificWorldJournal 2012 , 764563, (2012)

This study assessed the prevalence of antibiotic-resistant Aeromonas species isolated from Alice and Fort Beaufort wastewater treatment plant in the Eastern Cape Province of South Africa. Antibiotic s...

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