2-十八烯酸单甘油酯

2-十八烯酸单甘油酯用途

2-Oleoylglycerol 是饮食中天然存在的脂质。2-Oleoylglycerol 是一种 GPR119 激动剂,在瞬时转染的 COS-7 细胞中激活 hGPR119 的 EC50 值为 2.5 μM。2-Oleoylglycerol 在体内刺激胰高血糖素样肽 1 (GLP-1) 分泌。

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2-十八烯酸单甘油酯名称

[ CAS 号 ]:
3443-84-3

[ 中文名 ]:
2-十八烯酸单甘油酯

[ 英文名 ]:
2-Oleoylglycerol

[中文别名 ]:

2-甘油单油酸酯

[英文别名 ]:

glycerine monooleate
2-o-Kresyloxy-glutarsaeure-diethylester
2-MONOOLEIN
1,3-dihydroxypropan-2-yl oleate
2-monooleoylglycerol
2-Oleoylglycerol
glycerin oleate

2-十八烯酸单甘油酯生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> GPR119

研究领域 >> 代谢疾病

[ 靶点 ]

IC50: 2.5 μM (hGPR119) (in COS-7 cells)[1]

[参考文献]

[1]. Hansen KB, et, al. 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. J Clin Endocrinol Metab. 2011 Sep;96(9):E1409-17.

[2]. Ghafouri N, et, al. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. Br J Pharmacol. 2004 Nov;143(6):774-84.

2-十八烯酸单甘油酯物理化学性质

[ 密度 ]:
0.969 g/cm3

[ 沸点 ]:
485.4ºC at 760mmHg

[ 分子式 ]:
C₂₁H₄₀O₄

[ 分子量 ]:
356.54000

[ 闪点 ]:
113ºC

[ 精确质量 ]:
356.29300

[ PSA ]:
66.76000

[ LogP ]:
4.92030

[ 外观性状 ]:
液体

[ 折射率 ]:
1.478

[ 储存条件 ]:
-20°C，密封，避光

2-十八烯酸单甘油酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

2-十八烯酸单甘油酯合成路线

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2-十八烯酸单甘油酯文献

Sensing of triacylglycerol in the gut: different mechanisms for fatty acids and 2-monoacylglycerol.

J. Physiol. 593(8) , 2097-109, (2015)

Sensing of dietary triacylglycerol in the proximal small intestine results in physiological, hormonal and behavioural responses. However, the exact physiological pathways linking intestinal fat sensin...

TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury.

Am. J. Physiol. Lung Cell. Mol. Physiol. 307(2) , L158-72, (2014)

The treatment of acute lung injury caused by exposure to reactive chemicals remains challenging because of the lack of mechanism-based therapeutic approaches. Recent studies have shown that transient ...

Identification of 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide (29) as an orally available MGAT2 inhibitor.

Bioorg. Med. Chem. 23 , 5922-31, (2015)

MGAT2 (monoacylglycerol acyltransferase 2) is expected to be an attractive target for the drug treatment of obesity, diabetes, and other disease. We describe our exploration and structure-activity rel...

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