三甲基秋水仙酸

三甲基秋水仙酸用途

Trimethylcolchicinic acid is an antimitotic agent disrupting microtubule action through the binding of tubulin and preventing polymerization. Has been shown to stimulate the intrinsic GTPase activity of tubulin. Induces apoptosis and activates the JNK/SAPK signals.

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三甲基秋水仙酸名称

[ CAS 号 ]:
3482-37-9

[ 中文名 ]:
三甲基秋水仙素酸

[ 英文名 ]:
Trimethylcolchicinic acid

[英文别名 ]:

trimethylcolchicinic acid

三甲基秋水仙酸物理化学性质

[ 密度 ]:
1.32g/cm3

[ 沸点 ]:
629ºC at 760mmHg

[ 熔点 ]:
>230ºC (dec.)

[ 分子式 ]:
C₁₉H₂₁NO₅

[ 分子量 ]:
343.37400

[ 闪点 ]:
334.2ºC

[ 精确质量 ]:
343.14200

[ PSA ]:
91.01000

[ LogP ]:
3.09150

[ 折射率 ]:
1.628

[ 储存条件 ]:
−20°C

三甲基秋水仙酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0960000

CHEMICAL NAME :: Colchicinic acid, trimethyl-

CAS REGISTRY NUMBER :: 3482-37-9

BEILSTEIN REFERENCE NO. :: 3008992

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C19-H21-N-O5

MOLECULAR WEIGHT :: 343.41

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JZ NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

REFERENCE :: CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 3,134,1950

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三甲基秋水仙酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
20/21/22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
GH0960000

三甲基秋水仙酸上下游产品

三甲基秋水仙酸上游产品

三甲基秋水仙酸下游产品

三甲基秋水仙酸文献

Resolution of liver fibrosis in chronic CCl4 administration in the rat after discontinuation of treatment: effect of silymarin, silibinin, colchicine and trimethylcolchicinic acid.

Basic Clin Pharmacol Toxicol. 96(5) , 375-80, (2005)

The purpose of this work was to obtain a suitable model of fibrosis, in which spontaneous reversion was minimal, to study the ability of silymarin, silibinin, colchicine and trimethylcolchicinic acid ...

Effect of colchicine and trimethylcolchicinic acid on CCl4-induced cirrhosis in the rat.

Pharmacol. Toxicol. 79(5) , 241-6, (1996)

Colchicine is one of the most promising drugs for the treatment of cirrhosis. However, due to its toxicity, other drugs are being evaluated and colchicine-like molecules may be good alternatives. The ...

The role of microtubules in pinocytosis. Inhibition of fluid-phase pinocytosis in the rat visceral yolk sac by mitoclasic and related agents.

Cell Biol. Int. Rep. 7(8) , 593-602, (1983)

Colchicine, demecolcine and vinblastine all effectively inhibited the pinocytic capture of 125I-labelled poly(vinylpyrrolidone) by rat visceral yolk sacs cultured in vitro. Complete inhibition did not...

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