异戊基丙二酸二乙酯

异戊基丙二酸二乙酯用途

Aprophen (Aprofene) 是一种抗毒蕈碱抑制剂。Aprophen 可用于中枢神经系统的研究。

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异戊基丙二酸二乙酯名称

[ CAS 号 ]:
3563-01-7

[ 中文名 ]:
异戊基丙二酸二乙酯

[ 英文名 ]:
Diethylaminoethyl

[英文别名 ]:

Aprofenum [INN-Latin]
Aprophenum
Aprofeno [INN-Spanish]
2-Diethylaminoethyl 2,2-diphenylpropionate
Aprofene
Aprofen
Aprophen

异戊基丙二酸二乙酯生物活性

[ 描述 ]:

Aprophen (Aprofene) 是一种抗毒蕈碱抑制剂。Aprophen 可用于中枢神经系统的研究。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> mAChR

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

研究领域 >> 神经疾病

[参考文献]

[1]. A comparison of the antimuscarinic properties of aprophen with those of some other anticholinergic drugs. Issue: MRL-R-794. Pages: 10 pp. Report 1980.

异戊基丙二酸二乙酯物理化学性质

[ 密度 ]:
1.041g/cm3

[ 沸点 ]:
434.8ºC at 760mmHg

[ 分子式 ]:
C₂₁H₂₇NO₂

[ 分子量 ]:
325.44500

[ 闪点 ]:
132.5ºC

[ 精确质量 ]:
325.20400

[ PSA ]:
29.54000

[ LogP ]:
3.87760

[ 折射率 ]:
1.537

异戊基丙二酸二乙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UF2032500

CHEMICAL NAME :: Propionic acid, 2,2-diphenyl-, 2-(diethylamino)ethyl ester

CAS REGISTRY NUMBER :: 3563-01-7

BEILSTEIN REFERENCE NO. :: 2509326

LAST UPDATED :: 199707

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H27-N-O2

MOLECULAR WEIGHT :: 325.49

WISWESSER LINE NOTATION :: 2N2&2OVX1&R&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 4,7,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 31,53,1968

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异戊基丙二酸二乙酯安全信息

[ 海关编码 ]:
2922199090

异戊基丙二酸二乙酯合成路线

详细合成路线

异戊基丙二酸二乙酯上下游产品

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异戊基丙二酸二乙酯下游产品

异戊基丙二酸二乙酯海关

[ 海关编码 ]: 2922199090

[ 中文概述 ]:
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%