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N-羟甲基烟酰胺

N-羟甲基烟酰胺用途

N-(Hydroxymethyl)nicotinamide 是一种抗微生物剂。

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N-羟甲基烟酰胺名称

[ CAS 号 ]:
3569-99-1

[ 中文名 ]:
N-羟甲基烟酰胺

[ 英文名 ]:
N-(Hydroxymethyl)nicotinamide

[中文别名 ]:

[英文别名 ]:

Pyridine-3-carboxylic Acid N-Methylolamide
3-Pyridinecarboxamide, N-(hydroxymethyl)-
Nicodine
Bilizorin
Cholamid
EINECS 222-668-4
Bilamid
3-Pyridinecarboxylic acid N-hydroxymethylamide
Nicoform
Cholamide

N-羟甲基烟酰胺生物活性

[ 描述 ]:

N-(Hydroxymethyl)nicotinamide 是一种抗微生物剂。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Zhang HK, et, al. [Study on the synthesis of N-hydroxymethyl-nicotinamide]. Yao Xue Xue Bao. 1992; 27(8): 629-31.

N-羟甲基烟酰胺物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
427.7±25.0 °C at 760 mmHg

[ 熔点 ]:
152-154 °C(lit.)

[ 分子式 ]:
C₇H₈N₂O₂

[ 分子量 ]:
152.151

[ 闪点 ]:
212.5±23.2 °C

[ 精确质量 ]:
152.058578

[ PSA ]:
62.22000

[ LogP ]:
-0.80

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.569

[ 储存条件 ]:
-20?C Freezer

N-羟甲基烟酰胺MSDS

详细MSDS(安全技术说明书)

N-羟甲基烟酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QS4476500

CHEMICAL NAME :: Nicotinamide, N-(hydroxymethyl)-

CAS REGISTRY NUMBER :: 3569-99-1

BEILSTEIN REFERENCE NO. :: 0128633

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H8-N2-O2

MOLECULAR WEIGHT :: 152.17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.305- 1972- Volume(issue)/page/year: 305,427,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 17,73,1960

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N-羟甲基烟酰胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QS4476500

[ 海关编码 ]:
2933399090

N-羟甲基烟酰胺上下游产品

N-羟甲基烟酰胺上游产品

N-羟甲基烟酰胺下游产品

N-羟甲基烟酰胺海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

N-羟甲基烟酰胺文献

[Study on the synthesis of N-hydroxymethyl-nicotinamide].

Yao Xue Xue Bao 27(8) , 629-31, (1992)

N-Hydroxymethyl-nicotinamide, an antimicrobic agent was prepared in good yield by treating nicotinamide with excess of formaldehyde in the presence of potassium carbonate. The condensation reaction wa...

Thin-layer chromatography-densitometric measurements for determination of N-(hydroxymethyl)nicotinamide in tablets and stability evaluation in solutions.

J. AOAC Int. 91(5) , 1186-90, (2008)

A thin-layer chromatography (TLC)-densitometric method was developed to determine N-(hydroxymethyl)nicotinamide in tablets and basic solutions along with nicotinic acid. Analysis was performed on sili...

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