去氧哈林通碱

去氧哈林通碱用途

脱氧三尖杉酯碱是从三尖杉属植物中分离出来的一种生物碱,具有显著的抗白血病活性[1]。

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去氧哈林通碱名称

[ CAS 号 ]:
36804-95-2

[ 中文名 ]:
去氧哈林通碱

[ 英文名 ]:
Cephalotaxine,3-[4-methyl (2R)-2-hydroxy-2-(3-methylbutyl)butanedioate]

[中文别名 ]:

脱氧三尖杉酯碱

[英文别名 ]:

(-)-deoxyharringtonine

去氧哈林通碱生物活性

[ 描述 ]:

脱氧三尖杉酯碱是从三尖杉属植物中分离出来的一种生物碱,具有显著的抗白血病活性[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

脱氧三尖杉酯碱作用于第388页白血病细胞的 IC50型值为 7.5 ng/mL此外,其对造血细胞系如 HL-60、HL-60/RV+、JURKAT、ALL3、NCEB1、JEKO、MOLT-3等具有极强的细胞毒活性[1]。

[参考文献]

[1]. Joseph D Eckelbarger, et al. Synthesis of antiproliferative Cephalotaxus esters and their evaluation against several human hematopoietic and solid tumor cell lines: uncovering differential susceptibilities to multidrug resistance. Chemistry. 2008;14(14):4293-306.

去氧哈林通碱物理化学性质

[ 密度 ]:
1.3g/cm3

[ 沸点 ]:
645.8ºC at 760mmHg

[ 分子式 ]:
C₂₈H₃₇NO₈

[ 分子量 ]:
515.59500

[ 闪点 ]:
344.4ºC

[ 精确质量 ]:
515.25200

[ PSA ]:
103.76000

[ LogP ]:
3.01360

[ 折射率 ]:
1.595

去氧哈林通碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FK0279000

CHEMICAL NAME :: Cephalotaxine, 4-methyl-, 2-hydroxy-2-(3-methylbutyl)butanedioate (ester), (3(R))-

CAS REGISTRY NUMBER :: 36804-95-2

LAST UPDATED :: 199209

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C28-H37-N-O8

MOLECULAR WEIGHT :: 515.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988