1,2-双(2-碘乙氧基)乙烷

1,2-双(2-碘乙氧基)乙烷用途

1,2-Bis(2-iodoethoxy)ethane 是一种 PROTAC linker,属于 PEG 类。1,2-Bis(2-iodoethoxy)ethane 可用于合成 MT802 (HY-122562) 和 SJF620 (HY-133137)。MT-802 和 SJF620 都是 PROTAC BTK 降解剂,DC50 分别为 1 和 7.9 nM。

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1,2-双(2-碘乙氧基)乙烷名称

[ CAS 号 ]:
36839-55-1

[ 中文名 ]:
1,2-双(2-碘乙氧基)乙烷

[ 英文名 ]:
Iodo-PEG3-Iodide

[中文别名 ]:

[英文别名 ]:

Ethylene Glycol Bis(2-iodoethyl) Ether
1,2-BIS(2-IODOETHOXY)ETHANE
MFCD00075008

1,2-双(2-碘乙氧基)乙烷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

PEGs

[体外研究]

1,2-双(2-碘乙氧基)乙烷是一种PROTAC连接剂,指的是PEG的组成。1,2-双(2-碘乙氧基)乙烷可用于合成MT802(HY-122562)和SJF620(HY-133137)等一系列质子交换树脂。PROTAC MT802(HY-122562)具有BTK专用配体,以及由聚乙二醇(PEG)连接剂1,2-双(2-碘氧基)乙烷连接的E3连接酶小脑(CRBN)专用配体[1]。

[参考文献]

[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.

1,2-双(2-碘乙氧基)乙烷物理化学性质

[ 密度 ]:
2.028 g/mL at 25 °C(lit.)

[ 沸点 ]:
293.5ºC at 760 mmHg

[ 分子式 ]:
C₆H₁₂I₂O₂

[ 分子量 ]:
369.96700

[ 闪点 ]:
>230 °F

[ 精确质量 ]:
369.89300

[ PSA ]:
18.46000

[ LogP ]:
1.88960

[ 折射率 ]:
n20/D 1.572(lit.)

[ 储存条件 ]:
室温

1,2-双(2-碘乙氧基)乙烷MSDS

1,2-双(2-碘乙氧基)乙烷安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2909199090

1,2-双(2-碘乙氧基)乙烷合成路线

1,2-双(2-碘乙氧基)乙烷上下游产品

1,2-双(2-碘乙氧基)乙烷上游产品

1,2-双(2-碘乙氧基)乙烷下游产品

1,2-双(2-碘乙氧基)乙烷海关

[ 海关编码 ]: 2909199090

[ 中文概述 ]:
2909199090. 其他无环醚及其卤化衍生物（包括磺化，硝化或亚硝化衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

1,2-双(2-碘乙氧基)乙烷文献

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