新霉胺

新霉胺用途

Neamine 是一种 Neomycin 的无毒衍生物,也是一种广谱氨基糖苷类抗生素。Neamine 是靶向血管生成素 (angiogenin) 的抗血管生成剂。Neamine 具有有效的抗菌,抗肿瘤和神经保护活性。

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新霉胺名称

[ CAS 号 ]:
3947-65-7

[ 中文名 ]:
新霉胺

[ 英文名 ]:
neamine

[中文别名 ]:

[英文别名 ]:

U-5214
Neomycin A
Negamicin
dekamycinv
Neamine
neomycina
neamin
nebramycinx

新霉胺生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 心血管疾病

研究领域 >> 感染

研究领域 >> 神经疾病

信号通路 >> 抗感染 >> 细菌

[体外研究]

Neamine(0.625-25μM；48小时；AsPC-1细胞)在0.625-25μM范围内以剂量依赖的方式抑制ANG介导的AsPC-1细胞增殖[1]。Neamine(100μM)也能有效地阻断ANG的核转位[1]。细胞增殖试验[1]细胞系：AsPC-1细胞浓度：0.625µM、1.25µM、2.5µM、5µM、10µM、25µM孵育时间：48小时结果：抑制血管生长素(ANG)诱导的AsPC-1细胞增殖。

[体内研究]

Neamine(30-60mg/kg；皮下注射；每日；连续14天；雄性Balb/c裸鼠)对AsPC-1异种移植模型具有抗肿瘤作用。Neamine降低肿瘤移植瘤血管紧张素、Ki-67和CD31的表达水平[1]。动物模型：雄性Balb/c裸鼠(4周龄)注射AsPC-1细胞[1]剂量：30mg/kg,60mg/kg给药：皮下注射；每日一次；共14d结果：对AsPC-1异种移植模型有抗肿瘤作用。

[参考文献]

[1]. Ya-Ping Liu, et al. Neamine Inhibits Growth of Pancreatic Cancer Cells in Vitro and in Vivo. J Huazhong Univ Sci Technolog Med Sci. 2016 Feb;36(1):82-87.

[2]. R Ning, et al. Neamine Induces Neuroprotection After Acute Ischemic Stroke in Type One Diabetic Rats. Neuroscience. 2014 Jan 17;257:76-85.

新霉胺物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
577.9±50.0 °C at 760 mmHg

[ 熔点 ]:
225.5°C (rough estimate)

[ 分子式 ]:
C₁₂H₂₆N₄O₆

[ 分子量 ]:
322.358

[ 闪点 ]:
303.3±30.1 °C

[ 精确质量 ]:
322.185242

[ PSA ]:
203.46000

[ LogP ]:
-2.78

[ 外观性状 ]:
米白色至浅黄色固体

[ 蒸汽压 ]:
0.0±3.6 mmHg at 25°C

[ 折射率 ]:
1.649

[ 储存条件 ]:
2-8°C，惰性气体

新霉胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QP3860000

CHEMICAL NAME :: Neomycin A

CAS REGISTRY NUMBER :: 3947-65-7

BEILSTEIN REFERENCE NO. :: 0026714

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H26-N4-O6

MOLECULAR WEIGHT :: 322.42

WISWESSER LINE NOTATION :: T6OTJ B1Z CQ DQ EZ FO- BL6TJ AZ CQ DQ EZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,664,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 27,677,1974

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新霉胺安全信息

[ 危害码 (欧洲) ]:
T

新霉胺文献

CuAAC-mediated diversification of aminoglycoside-arginine conjugate mimics by non-reducing di- and trisaccharides.

Carbohydr. Res. 371 , 61-7, (2013)

Di- and triguanidinylation of trehalose, sucrose, and melizitose has been achieved via a Huisgen-cycloaddition approach. They can serve as aminoglycoside-arginine conjugate mimics, which has been demo...

Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.

J. Virol. 87(21) , 11806-20, (2013)

Angiogenin (ANG) is a 14-kDa multifunctional proangiogenic secreted protein whose expression level correlates with the aggressiveness of several tumors. We observed increased ANG expression and secret...

Investigation of RNA-ligand interactions by 19F NMR spectroscopy using fluorinated probes.

Angew. Chem. Int. Ed. Engl. 51(38) , 9530-4, (2012)

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新霉胺