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6-氟吲哚

6-氟吲哚用途

6-氟吲哚是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

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6-氟吲哚名称

[ CAS 号 ]:
399-51-9

[ 中文名 ]:
6-氟吲哚

[ 英文名 ]:
6-fluoroindole

[英文别名 ]:

6-FLUOROINDOLE FOR SYNTHESIS 25 G
6-Fluoroindole
6-fluoro indole
6-FLUORO-2-IODOBENZALDEHYDE
6-Fluoro-1H-indole
1H-Indole, 5-fluoro-
5-Fluoro-1H-indole
MFCD00056933
5-Fluoro indole
6-FLUOROINDOLE FOR SYNTHESIS 5 G

6-氟吲哚生物活性

[ 描述 ]:

6-氟吲哚是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

6-氟吲哚在色氨酸双加氧酶抑制剂吡啶基-乙烯-吲哚的合成中用作试剂,吡啶基-乙烯-吲哚用作潜在的抗癌免疫调节剂。它还用作抗真菌剂和抗菌剂。此外,它还是一种有效的选择性 5个-羟色胺再摄取抑制剂。除此之外,它还用作艾滋病病毒1型附着的抑制剂。

6-氟吲哚物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
258.0±13.0 °C at 760 mmHg

[ 熔点 ]:
72-76 °C(lit.)

[ 分子式 ]:
C₈H₆FN

[ 分子量 ]:
135.14

[ 闪点 ]:
109.9±19.8 °C

[ 精确质量 ]:
135.048431

[ PSA ]:
15.79000

[ LogP ]:
2.19

[ 外观性状 ]:
米色-棕色结晶粉末

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.646

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
不溶

6-氟吲哚MSDS

6-氟吲哚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

6-氟吲哚合成路线

6-氟吲哚上下游产品

6-氟吲哚上游产品

6-氟吲哚下游产品

6-氟吲哚海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6-氟吲哚文献

Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.

J. Med. Chem. 54 , 5320, (2011)

Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance. IDO inhibition is thus an active...

Ionization potentials of fluoroindoles and the origin of nonexponential tryptophan fluorescence decay in proteins.

J. Am. Chem. Soc. 127(11) , 4104-13, (2005)

This work reports an explanation for the unusual monoexponential fluorescence decay of 5-fluorotryptophan (5FTrp) in single-Trp mutant proteins [Broos, J.; Maddalena, F.; Hesp, B. H. J. Am. Chem. Soc....

Discovery of novel N-β-D-xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes.

J. Med. Chem. 54 , 166, (2011)

A novel series of N-linked β-D-xylosides were synthesized and evaluated for inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) in a cell-based assay. Of these, the 4-chloro-3...

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