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顺式-N-(2-苯基环戊基)-氮杂环十四碳-1-烯-2-胺盐酸盐

用途

MDL12330A (RMI12330A) 是一种 adenyl cyclase 抑制剂。MDL12330A 抑制抗利尿激素对短路电流 (SCC) 的作用。MDL12330A 也是 cAMP phosphodiesterase 的抑制剂。

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名称

[ CAS 号 ]:
40297-09-4

[ 中文名 ]:
顺式-N-(2-苯基环戊基)-氮杂环十四碳-1-烯-2-胺盐酸盐

[ 英文名 ]:
MDL 12330A hydrochloride

[英文别名 ]:

MFCD00210204

生物活性

[ 描述 ]:

MDL12330A (RMI12330A) 是一种 adenyl cyclase 抑制剂。MDL12330A 抑制抗利尿激素对短路电流 (SCC) 的作用。MDL12330A 也是 cAMP phosphodiesterase 的抑制剂。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)

研究领域 >> 其他

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷酸环化酶

[参考文献]

[1]. Lippe C, et al. Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenyl cyclase inhibitors MDL12330A and SQ22536. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1991;99(1-2):209-11.

物理化学性质

[ 沸点 ]:
515ºC at 760 mmHg

[ 熔点 ]:
148 - 152 °C

[ 分子式 ]:
C₂₃H₃₇ClN₂

[ 分子量 ]:
377.01

[ 闪点 ]:
265.2ºC

[ 精确质量 ]:
376.26500

[ PSA ]:
24.39000

[ LogP ]:
6.85390

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
2-8°C

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Apparent PKA activity responds to intermittent hypoxia in bone cells: a redox pathway?

Am. J. Physiol. Heart Circ. Physiol. 299 , 225-35, (2010)

We studied hypoxia-induced dynamic changes in the balance between PKA and PKA-counteracting phosphatases in the microfluidic environment in single cells using picosecond fluorescence spectroscopy and ...

Stimulating effects of dopamine on chloride transport across the rat caudal epididymal epithelium in culture.

Biol. Reprod. 80(1) , 13-23, (2009)

The present study investigated the effects of dopamine on chloride transport across cultured rat caudal epididymal epithelium. The results showed that dopamine induced a biphasic short-circuit current...

Dopamine D1 receptors mediate dopamine-induced duodenal epithelial ion transport in rats.

Transl. Res. 161(6) , 486-94, (2013)

Dopamine (DA) is synthesized in gastrointestinal epithelial cells and performs important regulatory effects on the duodenal mucosa. However, the underlying mechanism remains largely unknown. The prese...

更多文献

顺式-N-(2-苯基环戊基)-氮杂环十四碳-1-烯-2-胺盐酸盐

用途

名称

生物活性

物理化学性质

安全信息

文献

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