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二氢叶酸

二氢叶酸用途

Dihydrofolic acid 是一种叶酸衍生物,由二氢叶酸还原酶作用转化为四氢叶酸。

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二氢叶酸名称

[ CAS 号 ]:
4033-27-6

[ 中文名 ]:
二氢叶酸

[ 英文名 ]:
Dihydrofolic acid

[英文别名 ]:

DIHYDROFOLIC ACID

二氢叶酸生物活性

[ 描述 ]:

Dihydrofolic acid 是一种叶酸衍生物,由二氢叶酸还原酶作用转化为四氢叶酸。

[ 相关类别 ]:

研究领域 >> 其他

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[相关活性小分子]

二氢叶酸物理化学性质

[ 密度 ]:
1.69g/cm3

[ 分子式 ]:
C₁₉H₂₁N₇O₆

[ 分子量 ]:
443.41300

[ 精确质量 ]:
443.15500

[ PSA ]:
211.89000

[ LogP ]:
0.62870

[ 折射率 ]:
1.762

[ 储存条件 ]:
-20°C

二氢叶酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

二氢叶酸合成路线

详细合成路线

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二氢叶酸文献

Synthetic polyglutamylation of dual-functional MTX ligands for enhanced combined cytotoxicity of poly(I:C) nanoplexes.

Mol. Pharm. 11(8) , 2631-9, (2014)

The antifolate drug methotrexate (MTX) can serve as a dual-functional ligand in antitumoral drug delivery, inducing both a folate receptor mediated cellular uptake and an intracellular cytotoxic actio...

A domino effect in antifolate drug action in Escherichia coli.

Nat. Chem. Biol. 4 , 602-8, (2008)

Mass spectrometry technologies for measurement of cellular metabolism are opening new avenues to explore drug activity. Trimethoprim is an antibiotic that inhibits bacterial dihydrofolate reductase (D...

Methotrexate-gelonin conjugate - an inhibitor of MCF-7 cells expressing the dihydrofolate receptor.

Biol. Chem. 395(12) , 1461-6, (2014)

An immunotoxin composed of gelonin, a basic ribosome-inactivating protein, type I of 30 kDa, isolated from the seeds of the Indian plant Gelonium multiflorum and methotrexate (MTX) has been studied as...

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