< 生产厂家价格 >

曲匹布通

曲匹布通用途

特立哌酮(AA 149)增加胆汁和胰液的分泌,加速胃肠道平滑肌松弛。特立哌酮可用于胆囊炎和功能性胃肠疾病的研究[1][2]。

点击显示

曲匹布通名称

[ CAS 号 ]:
41826-92-0

[ 中文名 ]:
三醚丁酮酸

[ 英文名 ]:
Trepibutone

[中文别名 ]:

[英文别名 ]:

2,4,5-Triethoxy-g-oxobenzenebutanoic Acid
Colibil
Benzenebutanoic acid, 2,4,5-triethoxy-γ-oxo-
MFCD00865221
4-Oxo-4-(2,4,5-triethoxyphenyl)butanoic acid
Trepibutone
AA 149
Triethoxybenzoylpropionate
Supacal

曲匹布通生物活性

[ 描述 ]:

特立哌酮(AA 149)增加胆汁和胰液的分泌,加速胃肠道平滑肌松弛。特立哌酮可用于胆囊炎和功能性胃肠疾病的研究[1][2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体外研究]

特雷哌丁酮(1-1000μM)可显著放松Oddi和十二指肠的括约肌[1]。

[体内研究]

特立哌酮(1-20 mg/kg；静脉注射一次)剂量依赖性地增加胆汁流量[2]。特立哌酮(10mg/kg；注射14C-赤藓糖醇后3h静脉注射)刺激小管胆汁形成,而不会增加胆道和胆管中的水分分泌和抑制胆汁重吸收[2]。动物模型：麻醉比格犬[2]剂量：1-20 mg/kg给药：静脉注射；结果：剂量依赖性地增加了狗的胆汁流量,并在剂量为10mg/kg时显示出胆汁流量的峰值增加。动物模型：Beagle犬注射14C-赤藓糖醇[2]剂量：10mg/kg给药：静脉注射；10毫克/千克；注射14C-赤藓糖醇后3h结果：增加了与小管胆汁流相关的胆汁流,刺激了小管胆液的形成。

曲匹布通物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
498.6±45.0 °C at 760 mmHg

[ 熔点 ]:
146-150ºC

[ 分子式 ]:
C₁₆H₂₂O₆

[ 分子量 ]:
310.342

[ 闪点 ]:
179.9±22.2 °C

[ 精确质量 ]:
310.141632

[ PSA ]:
82.06000

[ LogP ]:
3.18

[ 外观性状 ]:
淡黄色晶体粉末

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.512

[ 储存条件 ]:
室温，密封，干燥

曲匹布通毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UF8440000

CHEMICAL NAME :: Propionic acid, 3-(2,4,5-triethoxybenzoyl)-

CAS REGISTRY NUMBER :: 41826-92-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C16-H22-O6

MOLECULAR WEIGHT :: 310.38

WISWESSER LINE NOTATION :: QV2VR BO2 DO2 EO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,811,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,811,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 570 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,811,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,811,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1310 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,1501,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 510 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,1501,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 625 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,1501,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,811,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9100 mg/kg/30D-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Endocrine - changes in thymus weight Blood - hemorrhage

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 36,263,1977

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 45500 mg/kg/26W-C

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 36,263,1977

点击显示

曲匹布通安全信息

[ 海关编码 ]:
2918990090

曲匹布通合成路线

详细合成路线

曲匹布通上下游产品

曲匹布通上游产品

曲匹布通下游产品

曲匹布通海关

[ 海关编码 ]: 2918990090

[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%