< 生产厂家价格 >

4-甲基邻苯二酚

4-甲基邻苯二酚用途

4-Methylcatechol,p-toluate 的代谢物,它既是 Catechol 2,3-Dioxygenase 的自杀性底物抑制剂。

点击显示

4-甲基邻苯二酚名称

[ CAS 号 ]:
452-86-8

[ 中文名 ]:
3,4-二羟基甲苯

[ 英文名 ]:
4-methylcatechol

[中文别名 ]:

[英文别名 ]:

5-Methylcatechol
2-Hydroxy-4-methylphenol
4-Methylbenzol-1,2-diol
1,2-Benzenediol, 4-methyl-
Homocatechol
1-Methyl-3,4-dihydroxybenzene
4-methyl-Pyrocatechol
p-Methylcatechol
1,2-Dihydroxy-4-methylbenzene
4-Methylpyrocatechol

4-甲基邻苯二酚生物活性

[ 描述 ]:

4-Methylcatechol,p-toluate 的代谢物,它既是 Catechol 2,3-Dioxygenase 的自杀性底物抑制剂。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

Catechol 2,3-Dioxygenase

[参考文献]

[1]. Okuta A, et al. Construction of chimeric catechol 2,3-dioxygenase exhibiting improved activity against the suicide inhibitor 4-methylcatechol. Appl Environ Microbiol. 2004 Mar;70(3):1804-10.

[相关活性小分子]

4-甲基邻苯二酚物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
247.7±20.0 °C at 760 mmHg

[ 熔点 ]:
67-69 °C(lit.)

[ 分子式 ]:
C₇H₈O₂

[ 分子量 ]:
124.137

[ 闪点 ]:
121.1±16.4 °C

[ 精确质量 ]:
124.052429

[ PSA ]:
40.46000

[ LogP ]:
1.34

[ 外观性状 ]:
灰白色至红色结晶粉末

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.595

[ 储存条件 ]:
室温

[ 水溶解性 ]:
soluble

4-甲基邻苯二酚MSDS

4-甲基邻苯二酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX1915000

CHEMICAL NAME :: Pyrocatechol, 4-methyl-

CAS REGISTRY NUMBER :: 452-86-8

BEILSTEIN REFERENCE NO. :: 0636512

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H8-O2

MOLECULAR WEIGHT :: 124.15

WISWESSER LINE NOTATION :: QR BQ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg/51W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 10 mg/L

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 14,251,1981

点击显示

4-甲基邻苯二酚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
3

[ RTECS号 ]:
UX1915000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2907299090

4-甲基邻苯二酚合成路线

4-甲基邻苯二酚上下游产品

4-甲基邻苯二酚上游产品

4-甲基邻苯二酚下游产品

4-甲基邻苯二酚制备

1.以天然4-甲基愈创木酚为原料经氧化制取。

2. 从苯-石油醚中得叶状体，从苯中得棱晶。

3. 烟草：OR，26。

点击显示

4-甲基邻苯二酚海关

[ 海关编码 ]: 2907299090

[ 中文概述 ]:
2907299090 其他多元酚，酚醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

4-甲基邻苯二酚文献

Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.

J. Med. Chem. 48 , 7234-42, (2005)

In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51 substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations needed to induce caspas...

Verifying the botanical authenticity of commercial tannins through sugars and simple phenols profiles.

Food Chem. 206 , 274-83, (2016)

Commercial tannins from several botanical sources and with different chemical and technological characteristics are used in the food and winemaking industries. Different ways to check their botanical ...

Quantitative analysis of catechol and 4-methylcatechol in human urine.

Food Chem. Toxicol. 20(5) , 587-90, (1982)

A method was developed for the quantitative analysis of catechol and 4-methylcatechol in human urine. [U-14C]Catechol was used as in internal standard. Urine was treated with beta-glucuronidase and su...

更多文献

4-甲基邻苯二酚

4-甲基邻苯二酚用途

4-甲基邻苯二酚名称

4-甲基邻苯二酚生物活性

4-甲基邻苯二酚物理化学性质

4-甲基邻苯二酚MSDS

详细MSDS(安全技术说明书)

4-甲基邻苯二酚毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

4-甲基邻苯二酚安全信息

4-甲基邻苯二酚合成路线

详细合成路线

4-甲基邻苯二酚上下游产品

4-甲基邻苯二酚上游产品

4-甲基邻苯二酚下游产品

4-甲基邻苯二酚制备

4-甲基邻苯二酚海关

4-甲基邻苯二酚文献

相关化工产品/化学物质：

推荐生产厂家/供应商：

相关化合物