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胆色素原

胆色素原用途

Porphobilinogen 可以作为一种光毒素,神经毒素和代谢毒素。

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胆色素原名称

[ CAS 号 ]:
487-90-1

[ 中文名 ]:
5-9氨基甲基)-4-(羧甲基)-1H-吡咯-3-丙酸

[ 英文名 ]:
Porphobilinogen

[中文别名 ]:

[英文别名 ]:

EINECS 207-666-3
Porphobilinogen
MFCD00005224

胆色素原生物活性

[ 描述 ]:

Porphobilinogen 可以作为一种光毒素,神经毒素和代谢毒素。

[ 相关类别 ]:

研究领域 >> 代谢疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

Porphobilinogen可以作为光毒素,神经毒素和内毒素。光毒素在暴露于光线时会导致细胞损伤。神经毒素会导致神经细胞和神经组织受损。内毒素是一种内源性产生的代谢物,在长期高水平引起不良健康影响[1]。

[参考文献]

[1]. Winkelman JW, et al. Neurotoxicity of tetraphenylporphinesulfonate TPPS4 and its relation to photodynamic therapy. Photochem Photobiol. 1987 Nov;46(5):801-7.

[相关活性小分子]

胆色素原物理化学性质

[ 密度 ]:
1.421g/cm3

[ 沸点 ]:
478.6ºC at 760 mmHg

[ 熔点 ]:
174-177ºC

[ 分子式 ]:
C₁₀H₁₄N₂O₄

[ 分子量 ]:
226.22900

[ 闪点 ]:
243.2ºC

[ 精确质量 ]:
226.09500

[ PSA ]:
116.41000

[ LogP ]:
0.81800

[ 蒸汽压 ]:
5.74E-10mmHg at 25°C

[ 折射率 ]:
1.621

[ 储存条件 ]:
-20°C

胆色素原安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

胆色素原合成路线

详细合成路线

胆色素原海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

胆色素原文献

Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.

FASEB J. 29 , 3889-98, (2015)

The ubiquitin system plays a critical role in muscle wasting. Previous work has focused on the roles of ubiquitination. However, a role for deubiquitination in this process has not been established. B...

Mass spectrometric characterisation of a condensation product between porphobilinogen and indolyl-3-acryloylglycine in urine of patients with acute intermittent porphyria.

J. Mass Spectrom. 50 , 929-37, (2015)

We document the presence of a previously unknown species in the urine of patients with acute intermittent porphyria (AIP). The compound was fully characterised by liquid chromatography tandem mass spe...

Crosstalk between the mesothelium and lymphomatous cells: insight into the mechanisms involved in the progression of body cavity lymphomas.

Cancer Med. 3(1) , 1-13, (2014)

The peculiar localization of body cavity lymphomas implies a specific contribution of the intracavitary microenvironment to the pathogenesis of these tumors. In this study, primary effusion lymphoma (...

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