< 生产厂家价格 >

4-哌啶甲酸

4-哌啶甲酸用途

异壬酸是GABAA受体部分激动剂[1]。

点击显示

4-哌啶甲酸名称

[ CAS 号 ]:
498-94-2

[ 中文名 ]:
4-哌啶甲酸

[ 英文名 ]:
Isonipecotic acid

[中文别名 ]:

[英文别名 ]:

Isonipecotic acid
4-Hexahydroisonicotinic acid
Piperidine-4-carboxylic acid
UNII-M5TZP1RWIE
4-Piperidinecarboxylic acid
Hexahydroisonicotinic acid
EINECS 207-872-3
MFCD00006004
Isonipecoticacid

4-哌啶甲酸生物活性

[ 描述 ]:

异壬酸是GABAA受体部分激动剂[1]。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> GABA受体

[ 靶点 ]

GABAA Receptor[1]

[体外研究]

异壬酸抑制[3H]GABA结合(2°C),IC50为0.33μM[2]。

[参考文献]

[1]. Krehan D, et al. Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA(C) receptor antagonists. Neurochem Int. 2003 Jun;42(7):561-5.

[2]. Falch E, et al. GABA-mimetic activity and effects on diazepam binding of aminosulphonic acids structurally related to piperidine-4-sulphonic acid. J Neurochem. 1985 Jan;44(1):68-75.

4-哌啶甲酸物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
265.8±33.0 °C at 760 mmHg

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C₆H₁₁NO₂

[ 分子量 ]:
129.157

[ 闪点 ]:
114.5±25.4 °C

[ 精确质量 ]:
129.078979

[ PSA ]:
49.33000

[ LogP ]:
-0.08

[ 外观性状 ]:
白色至淡的粉红色-米色粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.479

[ 储存条件 ]:
Store at 0-5°C

[ 水溶解性 ]:
soluble

4-哌啶甲酸MSDS

4-哌啶甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NS5150000

CHEMICAL NAME :: Isonipecotic acid

CAS REGISTRY NUMBER :: 498-94-2

BEILSTEIN REFERENCE NO. :: 0112553

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C6-H11-N-O2

MOLECULAR WEIGHT :: 129.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 23,1343,1968

点击显示

4-哌啶甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NS5150000

[ 海关编码 ]:
2942000000

4-哌啶甲酸合成路线

4-哌啶甲酸上下游产品

4-哌啶甲酸上游产品

4-哌啶甲酸下游产品

4-哌啶甲酸海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-哌啶甲酸文献

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).

Bioorg. Med. Chem. 19 , 6409-18, (2011)

The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitati...

更多文献