Mezilamine

Mezilamine用途

Mezilamine是一种强效的抗多巴胺药物。Mezilamine诱导大鼠皮质切片电刺激3H-去甲肾上腺素溢出的浓度依赖性增加,而不影响基础溢出。Mezilamine作为突触前α肾上腺素受体拮抗剂和突触后α肾上腺素受体激动剂[1]。

点击显示

Mezilamine名称

[ CAS 号 ]:
50335-55-2

[ 英文名 ]:
Mezilamine

[英文别名 ]:

Mezilamine生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 内分泌

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 神经疾病

[体外研究]

夹层胺(1、5、10μM)导致 3小时刺激的溢出浓度依赖性增加,而不影响皮质切片的自发流出[1]。

[参考文献]

[1]. G Le Fur, et al. Mezilamine, a new dopamine antagonist, blocks presynaptic but stimulates postsynaptic alpha-adrenoceptors. Eur J Pharmacol. 1979 Oct 15;58(4):359-67.

Mezilamine物理化学性质

[ 密度 ]:
1.32g/cm3

[ 沸点 ]:
440.2ºC at 760 mmHg

[ 分子式 ]:
C₁₁H₁₈ClN₅S

[ 分子量 ]:
287.81200

[ 闪点 ]:
220ºC

[ 精确质量 ]:
287.09700

[ PSA ]:
69.59000

[ LogP ]:
1.72130

[ 折射率 ]:
1.627

Mezilamine毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV8126000

CHEMICAL NAME :: Pyrimidine, 4-chloro-2-(methylamino)-5-(methylthio)-6-(4-methyl-1 -piperazinyl)-

CAS REGISTRY NUMBER :: 50335-55-2

BEILSTEIN REFERENCE NO. :: 0666978

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C11-H18-Cl-N5-S

MOLECULAR WEIGHT :: 287.85

WISWESSER LINE NOTATION :: T6N DNTJ A1 D- DT6N CNJ BM1 ES1 FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 2,742,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 2,742,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 330 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 2,742,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 2,742,1977

点击显示

Mezilamine安全信息

[ 海关编码 ]:
2933990090

Mezilamine合成路线

详细合成路线

Mezilamine上下游产品

Mezilamine上游产品

Mezilamine下游产品

Mezilamine海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%