烟肼酰胺
烟肼酰胺用途
烟肼酰胺名称
[ CAS 号 ]:
51-12-7
[ 中文名 ]:
尼亚酰铵
[ 英文名 ]:
Nialamide
[中文别名 ]:
[英文别名 ]:
- 4-pyridinecarboxylic acid
- Nialamid
- EINECS 200-079-3
- Niamidal
- Niamid
- Psicodisten
- MFCD00010106
- 2-{3-oxo-3-[(phenylmethyl)amino]propyl}hydrazide
- Novazid
- Niazin
烟肼酰胺生物活性
烟肼酰胺物理化学性质
[ 密度 ]:
1.203g/cm3
[ 沸点 ]:
538.1ºC at 760mmHg
[ 熔点 ]:
152-154ºC(lit.)
[ 分子式 ]:
C16H18N4O2
[ 分子量 ]:
298.34000
[ 闪点 ]:
279.2ºC
[ 精确质量 ]:
298.14300
[ PSA ]:
83.12000
[ LogP ]:
2.19520
[ 折射率 ]:
1.589
[ 储存条件 ]:
通风低温干燥
[ 水溶解性 ]:
ethanol: clear to hazy
烟肼酰胺MSDS
烟肼酰胺毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NS1225000
- CHEMICAL NAME :
- Isonicotinic acid, 2-(2-(benzylcarbamoyl)ethyl)hydrazide
- CAS REGISTRY NUMBER :
- 51-12-7
- BEILSTEIN REFERENCE NO. :
- 0492941
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C16-H18-N4-O2
- MOLECULAR WEIGHT :
- 298.38
- WISWESSER LINE NOTATION :
- T6NJ DVMM2VM1R
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1700 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 760 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 590 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 54600 mg/kg/26W-C
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 24 mg/kg
- SEX/DURATION :
- female 1-6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- TYPE OF TEST :
- DNA damage
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 435 mg/kg
- REFERENCE :
- JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 9,287,1982 *** REVIEWS *** TOXICOLOGY REVIEW IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued. Volume(issue)/page/year: 2,209,1975 TOXICOLOGY REVIEW HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978- Volume(issue)/page/year: 55,527,1980
烟肼酰胺安全信息
[ 符号 ]:
GHS07, GHS08
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302 + H312 + H332-H315-H319-H335-H351
[ 警示性声明 ]:
P261-P280-P305 + P351 + P338
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xn
[ 风险声明 (欧洲) ]:
20/21/22-36/37/38-40
[ 安全声明 (欧洲) ]:
S22;S26;S36
[ 危险品运输编码 ]:
UN 3249
[ WGK德国 ]:
3
[ RTECS号 ]:
NS1225000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1(b)
[ 海关编码 ]:
2933399090
烟肼酰胺制备
由异烟酰肼为原料制得。
烟肼酰胺海关
[ 海关编码 ]: 2933399090
[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
烟肼酰胺文献
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(3) , 285-90, (2009)
An LC-MS/MS method for the determination of isoniazid in human plasma was developed and validated. Human plasma aliquots of 100 microL were used for analysis. The assay used nialamide as the internal ...
UWA-121, a mixed dopamine and serotonin re-uptake inhibitor, enhances L-DOPA anti-parkinsonian action without worsening dyskinesia or psychosis-like behaviours in the MPTP-lesioned common marmoset.Neuropharmacology 82 , 76-87, (2014)
L-3,4-Dihydroxyphenylalanine (L-DOPA) is the most effective treatment for Parkinson's disease (PD), but its long-term administration is complicated by wearing-off and dyskinesia. UWA-101, a dual, equi...
Spinal cord injury enables aromatic L-amino acid decarboxylase cells to synthesize monoamines.J. Neurosci. 34(36) , 11984-2000, (2014)
Serotonin (5-HT), an important modulator of both sensory and motor functions in the mammalian spinal cord, originates mainly in the raphe nuclei of the brainstem. However, following complete transecti...
推荐生产厂家/供应商：
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥650.0/1g
￥需询单/1g
￥需询单/1g
￥需询单/1g
联系人：阿拉丁李高志
产品详情：尼亚酰铵
查看所有供应商请点击：
相关化合物
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