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甲磺酸雷沙吉兰

甲磺酸雷沙吉兰用途

Rasagiline甲磺酸盐是MAO-B抑制剂,可作用于原发性帕金森病。

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甲磺酸雷沙吉兰名称

[ CAS 号 ]:
161735-79-1

[ 中文名 ]:
甲磺酸雷沙吉兰

[ 英文名 ]:
Rasagiline mesylate

[中文别名 ]:

[英文别名 ]:

Rasagiline mesylate
Rasagiline (mesylate)

甲磺酸雷沙吉兰生物活性

[ 描述 ]:

Rasagiline甲磺酸盐是MAO-B抑制剂,可作用于原发性帕金森病。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 神经信号通路 >> 单胺氧化酶

研究领域 >> 神经疾病

[参考文献]

[1]. Weinreb, O., et al., Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity. Prog Neurobiol, 2010. 92(3): p. 330-44.

[2]. Leegwater-Kim, J. and E. Bortan, The role of rasagiline in the treatment of Parkinson's disease. Clin Interv Aging, 2010. 5: p. 149-56.

[3]. Chen, J.J., D.M. Swope, and K. Dashtipour, Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson's disease. Clin Ther, 2007. 29(9): p. 1825-49.

[4]. Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9(15):12137-12153.

[相关活性小分子]

甲磺酸雷沙吉兰物理化学性质

[ 密度 ]:
1.05 g/cm3

[ 沸点 ]:
305.5ºC at 760 mmHg

[ 熔点 ]:
155-158°C

[ 分子式 ]:
C₁₃H₁₇NO₃S

[ 分子量 ]:
267.344

[ 闪点 ]:
146.8ºC

[ 精确质量 ]:
267.092926

[ PSA ]:
74.78000

[ LogP ]:
2.87240

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.000816mmHg at 25°C

[ 储存条件 ]:
-20°C Freezer

甲磺酸雷沙吉兰MSDS

甲磺酸雷沙吉兰安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2921499090

甲磺酸雷沙吉兰合成路线

甲磺酸雷沙吉兰上下游产品

甲磺酸雷沙吉兰上游产品

甲磺酸雷沙吉兰下游产品

甲磺酸雷沙吉兰海关

[ 海关编码 ]: 2921499090

[ 中文概述 ]:
2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

甲磺酸雷沙吉兰文献

Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial.

Lancet 365(9463) , 947-54, (2005)

Rasagiline mesylate is a novel drug for Parkinson's disease with selective, irreversible monoamine oxidase B (MAO-B) inhibitor activity, and is effective as monotherapy in early disease. This study in...

Rasagiline mesylate, a new MAO-B inhibitor for the treatment of Parkinson's disease: a double-blind study as adjunctive therapy to levodopa.

Clin. Neuropharmacol. 23(6) , 324-30, (2000)

Rasagiline mesylate (TVP-1012) is a potent, selective, non-reversible MAO-B inhibitor, without the tyramine-potentiating effect and with neuroprotective activities. The benefit of rasagiline as monoth...

Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor.

Neuroreport 9(4) , 703-7, (1998)

Both deprenyl and rasagiline (R(+)-N-propargyl-1-aminoindane mesylate), at a concentration of 1-10 microM, increased survival in vitro of rat E14 mesencephalic dopaminergic neurons that had been prime...

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甲磺酸雷沙吉兰

甲磺酸雷沙吉兰用途

甲磺酸雷沙吉兰名称

甲磺酸雷沙吉兰生物活性

甲磺酸雷沙吉兰物理化学性质

甲磺酸雷沙吉兰MSDS

详细MSDS(安全技术说明书)

甲磺酸雷沙吉兰安全信息

甲磺酸雷沙吉兰合成路线

详细合成路线

甲磺酸雷沙吉兰上下游产品

甲磺酸雷沙吉兰上游产品

甲磺酸雷沙吉兰下游产品

甲磺酸雷沙吉兰海关

甲磺酸雷沙吉兰文献

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