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米那卜林盐酸盐

米那卜林盐酸盐用途

Minaprine是单胺氧化酶MAO-A可逆性抑制剂,还对乙酰胆碱酯酶有微弱抑制,抗抑郁类化合物。

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米那卜林盐酸盐名称

[ CAS 号 ]:
25905-77-5

[ 中文名 ]:
米那卜林

[ 英文名 ]:
Minaprine

[中文别名 ]:

[英文别名 ]:

TS-370
Minaprin diHCl
MINAPRIN DIHYDROCHLORIDE
MINAPRINE HYDROCHLORIDE
MINAPRINE DIHYDROCHLORIDE
minaprin

米那卜林盐酸盐生物活性

[ 描述 ]:

Minaprine是单胺氧化酶MAO-A可逆性抑制剂,还对乙酰胆碱酯酶有微弱抑制,抗抑郁类化合物。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 单胺氧化酶

研究领域 >> 神经疾病

[参考文献]

[1]. Kan JP, et al. Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat. Biochem Pharmacol. 1986 Mar 15;35(6):973-8.

[2]. Contreras JM, et al. Aminopyridazines as acetylcholinesterase inhibitors. J Med Chem. 1999 Feb 25;42(4):730-41.

[相关活性小分子]

米那卜林盐酸盐物理化学性质

[ 密度 ]:
1.156g/cm3

[ 沸点 ]:
531.2ºC at 760 mmHg

[ 熔点 ]:
122°

[ 分子式 ]:
C₁₇H₂₂N₄O

[ 分子量 ]:
298.38

[ 闪点 ]:
275.1ºC

[ PSA ]:
50.28000

[ LogP ]:
3.81100

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
2.29E-11mmHg at 25°C

[ 折射率 ]:
1.595

[ 储存条件 ]:
-20℃

米那卜林盐酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QE3477830

[ 海关编码 ]:
2934999090

米那卜林盐酸盐合成路线

详细合成路线

米那卜林盐酸盐上下游产品

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米那卜林盐酸盐下游产品

米那卜林盐酸盐海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

米那卜林盐酸盐文献

Multicentric double-blind study comparing efficacy and safety of minaprine and imipramine in dysthymic disorders.

Neuropsychobiology 31(2) , 68-75, (1995)

This multicentre study compares the therapeutic efficacy and safety of minaprine (200 mg) to that of imipramine (50, 75, 100 mg) in the treatment of patients over 40 years suffering from dysthymic dis...

Computerised psychomotor performance testing: a comparative study of the single dose pharmacodynamics of minaprine and amitriptyline in young and elderly subjects.

Br. J. Clin. Pharmacol. 36(4) , 376-9, (1993)

The psychomotor and cardiovascular effects of minaprine 100 mg, a novel antidepressant, were compared with amitriptyline 25 mg, as a positive control, and placebo in a single dose randomised double-bl...

Cholinomimetic activity of minaprine is related to the amelioration of delayed neuronal death in gerbils.

Physiol. Behav. 52(1) , 141-7, (1992)

We attempted to determine if the cholinomimetic activity of the psychotropic drug minaprine was related to the amelioration of the delayed neuronal death induced by cerebral ischemia in Mongolian gerb...

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