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1-氯-2-甲基-1-丙烯

1-氯-2-甲基-1-丙烯用途

有机合成。

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1-氯-2-甲基-1-丙烯名称

[ CAS 号 ]:
513-37-1

[ 中文名 ]:
1-氯-2-甲基-1-丙烯

[ 英文名 ]:
1-chloro-2-methylpropene

[英文别名 ]:

1-CHLORO-2-METHYL-1-PROPENE
MFCD00000924
3-chloro-2-methylpropene
EINECS 208-158-4
Propene,1-chloro-2-methyl
1-chloroisobutene
1-chloro-2-methylprop-2-ene
1-Chloro-2-methylpropene
1-Propene,1-chloro-2-methyl
Isocrotyl chloride

1-氯-2-甲基-1-丙烯物理化学性质

[ 密度 ]:
0.911g/cm3

[ 沸点 ]:
68.1ºC at 760mmHg

[ 熔点 ]:
-96°C (estimate)

[ 分子式 ]:
C₄H₇Cl

[ 分子量 ]:
90.55140

[ 闪点 ]:
30 °F

[ 精确质量 ]:
90.02360

[ LogP ]:
2.14890

[ 折射率 ]:
n20/D 1.424(lit.)

[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开存放,不宜久储,以防聚合

1-氯-2-甲基-1-丙烯MSDS

1-氯-2-甲基-1-丙烯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UC8045000

CHEMICAL NAME :: Propene, 1-chloro-2-methyl-

CAS REGISTRY NUMBER :: 513-37-1

BEILSTEIN REFERENCE NO. :: 1733843

LAST UPDATED :: 199710

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C4-H7-Cl

MOLECULAR WEIGHT :: 90.56

WISWESSER LINE NOTATION :: G1UY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4465 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3160 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 181 gm/m3

TOXIC EFFECTS :: Behavioral - general anesthetic Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17500 mg/kg/14D-I

TOXIC EFFECTS :: Behavioral - muscle weakness Musculoskeletal - other changes Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 48750 mg/kg/13W-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - necrotic changes Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14 gm/kg/14D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 48750 mg/kg/13W-I

TOXIC EFFECTS :: Blood - changes in spleen Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 51500 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 51 gm/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 gm/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Heritable translocation test

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 500 mg/L

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-316,1986 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,315,1995 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,315,1995 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,315,1995 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.3 mg/m3;Skin JAN 1993

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1-氯-2-甲基-1-丙烯安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H311-H315-H319-H330-H335-H350

[ 警示性声明 ]:
P201-P210-P260-P280-P284-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
45-11-23/24/25-36/37/38

[ 安全声明 (欧洲) ]:
S16;S27;S45;S53;S36/S37/S39

[ 危险品运输编码 ]:
UN 1993 3/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
UC8045000

[ 包装等级 ]:
II

[ 危险类别 ]:
3.1

[ 海关编码 ]:
2903299090

1-氯-2-甲基-1-丙烯合成路线

1-氯-2-甲基-1-丙烯上下游产品

1-氯-2-甲基-1-丙烯上游产品

1-氯-2-甲基-1-丙烯下游产品

1-氯-2-甲基-1-丙烯海关

[ 海关编码 ]: 2903299090

[ 中文概述 ]:
HS: 2903299090. 其他无环烃的不饱和氯化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903299090 other unsaturated chlorinated derivatives of acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

1-氯-2-甲基-1-丙烯文献

Comparative metabolism and disposition of 1-chloro- and 3-chloro-2-methylpropene in rats and mice.

Drug Metab. Dispos. 15(1) , 91-6, (1987)

A recent 2-year carcinogenicity study found that gavage administration of 3-chloro-2-methylpropene (CMP), containing 5% 1-chloro-2-methylpropene (dimethylvinyl chloride, DMVC), caused forestomach neop...

Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic - example: 1-methylcyclopropene and its impurities (1-chloro-2-methylpropene and 3-chloro-2-methylpropene).

Food Chem. Toxicol. 48 Suppl 1 , S81-8, (2010)

The chlorinated impurities of 1-methylcyclopropene possess weak mutagenicity and are carcinogenic in rodent bioassays. Dose-response modelling of the data for 1-chloro-2-methylpropene gave a BMDL10 fo...

Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program.

Environ. Mol. Mutagen. 23(1) , 51-63, (1994)

Fifty chemicals were tested for mutagenic activity in post-meiotic and meiotic germ cells of male Drosophila melanogaster using the sex-linked recessive lethal (SLRL) assay. As in the previous studies...

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