吴耳酸

吴耳酸用途

Vulpinic acid是一种地衣代谢物,可减少H2O2诱导的人脐静脉内皮细胞(HUVEC)活性氧生成、氧化应激和氧化应激相关损伤。外阴酸对葡萄球菌、肠球菌和厌氧菌有活性。外阴酸具有动脉粥样硬化研究的潜力[1][2]。
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吴耳酸名称

[ CAS 号 ]:
521-52-8

[ 中文名 ]:
吴耳酸

[ 英文名 ]:
Vulpic acid

[中文别名 ]:

[英文别名 ]:

吴耳酸生物活性

[ 描述 ]:

Vulpinic acid是一种地衣代谢物,可减少H2O2诱导的人脐静脉内皮细胞(HUVEC)活性氧生成、氧化应激和氧化应激相关损伤。外阴酸对葡萄球菌、肠球菌和厌氧菌有活性。外阴酸具有动脉粥样硬化研究的潜力[1][2]。

[ 相关类别 ]:

研究领域 >> 感染
研究领域 >> 炎症/免疫
信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. E Sahin, et al. Vulpinic acid, a lichen metabolite, emerges as a potential drug candidate in the therapy of oxidative stress-related diseases, such as atherosclerosis. Hum Exp Toxicol. 2019 Jun;38(6):675-684.

[2]. M Lauterwein, et al. In vitro activities of the lichen secondary metabolites vulpinic acid, (+)-usnic acid, and (-)-usnic acid against aerobic and anaerobic microorganisms. Antimicrob Agents Chemother. 1995 Nov;39(11):2541-3.

吴耳酸物理化学性质

[ 密度 ]:
1.375g/cm3

[ 沸点 ]:
568.8ºC at 760mmHg

[ 熔点 ]:
146-148ºC

[ 分子式 ]:
C19H14O5

[ 分子量 ]:
322.31

[ 闪点 ]:
210.2ºC

[ 精确质量 ]:
322.08400

[ PSA ]:
72.83000

[ LogP ]:
3.09680

[ 折射率 ]:
1.656

[ 储存条件 ]:
-20°C Freezer

吴耳酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HF3500000
CHEMICAL NAME :
Delta(sup 2(5H),alpha)-furanacetic acid, 3-hydroxy-5-oxo-alpha,4-diphenyl-, methyl ester
CAS REGISTRY NUMBER :
521-52-8
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C19-H14-O5
MOLECULAR WEIGHT :
322.33
WISWESSER LINE NOTATION :
T5VOYJ CUYR&VO1 DQ ER

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,30,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 2,109,1946
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02804
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吴耳酸安全信息

[ 风险声明 (欧洲) ]:
28

[ 安全声明 (欧洲) ]:
1-22-45

[ 危险品运输编码 ]:
UN 3172

吴耳酸合成路线

详细合成路线

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