四甲基姜黄素

四甲基姜黄素用途

Tetramethylcurcumin (FLLL31) 是来自于姜黄素,通过选择性结合 Janus 激酶 2 和 STAT3 Src 同源性 2 结构域来特异性抑制 STAT3 的磷酸化。Tetramethylcurcumin 具有抗炎和抗癌作用。

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四甲基姜黄素名称

[ CAS 号 ]:
52328-97-9

[ 中文名 ]:
四甲基姜黄素

[ 英文名 ]:
Tetramethylcurcumin

[英文别名 ]:

FLLL31
Tetramethylcurcumin

四甲基姜黄素生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 干细胞及 Wnt 通路 >> STAT

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> JAK/STAT信号通路 >> STAT

研究领域 >> 炎症/免疫

[ 靶点 ]

STAT3

[体外研究]

四甲基姜黄素(FLLL31；2.5和5μM；24小时)下调MDA-MB-231乳腺癌和PANC-1胰腺癌细胞的STAT3磷酸化和DNA结合活性[1]。四甲基姜黄素抑制细胞活力,抑制细胞侵袭。四甲基姜黄素在体外是STAT3磷酸化、DNA结合活性和反式激活的有效抑制剂,导致胰腺癌和乳腺癌细胞系中多种致癌过程的障碍和凋亡的诱导[1]。

[参考文献]

[1]. Lin L, et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res. 2010 Mar 15;70(6):2445-54.

[2]. Yuan S, et al. FLLL31, a derivative of curcumin, attenuates airway inflammation in a multi-allergen challenged mouse model. Int Immunopharmacol. 2014 Jul;21(1):128-36.

四甲基姜黄素物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
594.5±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₅H₂₈O₆

[ 分子量 ]:
424.486

[ 闪点 ]:
255.1±30.2 °C

[ 精确质量 ]:
424.188599

[ PSA ]:
71.06000

[ LogP ]:
4.81

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.575

[ 储存条件 ]:
2-8°C，干燥，密封

四甲基姜黄素MSDS

四甲基姜黄素安全信息

[ 危害声明 ]:
H413

[ 危害码 (欧洲) ]:
N

[ 危险品运输编码 ]:
NONH for all modes of transport

四甲基姜黄素合成路线

四甲基姜黄素上下游产品

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四甲基姜黄素下游产品

四甲基姜黄素文献

Interleukin-17 Stimulates STAT3-Mediated Endothelial Cell Activation for Neutrophil Recruitment.

Cell Physiol. Biochem. 36 , 2340-56, (2015)

Interleukin-17 (IL-17) is a major pro-inflammatory cytokine that initiates and maintains inflammation. However, the molecular mechanisms as to how IL-17 influences endothelial cells to promote neutrop...

Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells.

PLoS ONE 10(3) , e0119857, (2015)

Alkylating agents are widely used chemotherapeutics in the treatment of many cancers, including leukemia, lymphoma, multiple myeloma, sarcoma, lung, breast and ovarian cancer. Melphalan is the most co...

Effect of LIF-withdrawal on acetylcholine synthesis in the embryonic stem cell line CGR8 is not mediated by STAT3, PI3Ks or cAMP/PKA pathways.

Int. Immunopharmacol. 29 , 115-8, (2015)

Acetylcholine (ACh) acts as a local cellular signaling molecule and is widely expressed in nature, including mammalian cells and embryonic stem cells. The murine embryonic stem cell line CGR8 synthesi...

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