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蝙蝠葛碱

蝙蝠葛碱用途

Dauricine 是存在于 Asiatic Moonseed Rhizome 中的一种双苯异喹啉生物碱,具有抗炎活性。Dauricine 通过抑制 NF-κB 激活,抑制结肠癌细胞的增值、侵袭,并诱导凋亡,且具有剂量依赖性。

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蝙蝠葛碱名称

[ CAS 号 ]:
524-17-4

[ 中文名 ]:
蝙蝠葛碱

[ 英文名 ]:
Dauricine

[中文别名 ]:

[英文别名 ]:

6,6'-Di-O-Methyldauricoline
Dauricine
Dauricine (8CI)
Menispermum dauricum DC Extract

蝙蝠葛碱生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 炎症/免疫

[参考文献]

[1]. Yang Z, et al. Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. J Cell Physiol. 2010 Oct;225(1):266-75.

蝙蝠葛碱物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
712.3±60.0 °C at 760 mmHg

[ 熔点 ]:
115ºC

[ 分子式 ]:
C₃₈H₄₄N₂O₆

[ 分子量 ]:
624.766

[ 闪点 ]:
384.6±32.9 °C

[ 精确质量 ]:
624.319946

[ PSA ]:
72.86000

[ LogP ]:
6.61

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.601

[ 储存条件 ]:
2-8 °C

蝙蝠葛碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SM9490000

CHEMICAL NAME :: Phenol, 4-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoqu inolinyl)methyl)-2-(4 -((1,2,3,4- tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)met hyl)phenoxy)-, (R-(R*,R*))-

CAS REGISTRY NUMBER :: 524-17-4

LAST UPDATED :: 198906

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C38-H44-N2-O6

MOLECULAR WEIGHT :: 624.84

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 23,182,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 185 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,419,1986