乙苯托品

乙苯托品用途

乙苯并托品(Ponalid)是一种毒蕈碱受体阻滞剂。乙苯托品是一种抗胆碱能和抗组胺能药物[1]。
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乙苯托品名称

[ CAS 号 ]:
524-83-4

[ 中文名 ]:
乙苯托品

[ 英文名 ]:
Ethybenztropine

[英文别名 ]:

乙苯托品生物活性

[ 描述 ]:

乙苯并托品(Ponalid)是一种毒蕈碱受体阻滞剂。乙苯托品是一种抗胆碱能和抗组胺能药物[1]。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> mAChR
信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
研究领域 >> 神经疾病

[ 靶点 ]

Muscarinic Receptor[1]


[体外研究]

乙苯托品(10μM)抑制新纹状体切片中3H-DA的摄取。

[体内研究]

乙苯并托品(25μg,中脑NRM微量注射)阻断家兔中缝正中核(NRM)微量注射卡巴胆碱的高热反应[1]。乙苯托品(30-60μg/kg,由第四脑室给药)可有效预防犬心律失常[2]。乙苯托品(50 mg/kg,i.p.)可减少大鼠体内儿茶酚胺的积累[3]。动物模型：心律失常犬[2]剂量：30-60μg/kg给药：第四脑室给药结果：产生轻微低血压(从未超过25mm Hg的下降)和轻微窦性心动过速。心律失常转为窦性心律。

[参考文献]

[1]. A K Saxena, et al. Presence of cholinoceptors in mesencephalic raphe nuclei concerned in thermoregulation in rabbits. Clin Exp Pharmacol Physiol. 1984 Mar-Apr;11(2):105-10.

[2]. M Rozear, et al. Effects of intracerebroventricular l-hyoscyamine, ethybenztropine and procaine on cardiac arrhythmias induced in dogs by pentylenetetrazol, picrotoxin or deslanoside. Int J Neuropharmacol. 1968 Jan;7(1):1-6.

[3]. LARS-OVE FARNEBO, et al. Effect of some antiparkinsonian drugs on catecholamine neurons. Journal of Pharmacy and Pharmacology, 1970, 22(10): 733-737.

乙苯托品物理化学性质

[ 密度 ]:
1.1g/cm3

[ 沸点 ]:
422.8ºC at 760mmHg

[ 分子式 ]:
C22H27NO

[ 分子量 ]:
321.45600

[ 闪点 ]:
124ºC

[ 精确质量 ]:
321.20900

[ PSA ]:
12.47000

[ LogP ]:
4.74580

[ 折射率 ]:
1.597

乙苯托品毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RD0525000
CHEMICAL NAME :
Nortropane, 3-(diphenylmethoxy)-8-ethyl-
CAS REGISTRY NUMBER :
524-83-4
LAST UPDATED :
199712
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C22-H27-N-O
MOLECULAR WEIGHT :
321.50
WISWESSER LINE NOTATION :
T56 A ANTJ A2 GOYR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,228,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #2235M
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
66 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,228,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - parasympatholytic
REFERENCE :
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 9,304,1970
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
215 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,228,1972
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,228,1972
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乙苯托品安全信息

[ 海关编码 ]:
2933990090

乙苯托品海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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