氯化飞燕草素

氯化飞燕草素用途

Delphinidin氯化物是一种花青素,从浆果和红酒中分离出来。Delphinidin氯化物显示内皮依赖性血管舒张。Delphinidin氯化物还可以调节JAK/STAT3和MAPKISE信号,诱导HCT116细胞凋亡[1][2][3]。

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氯化飞燕草素名称

[ CAS 号 ]:
528-53-0

[ 中文名 ]:
氯化花翠素

[ 英文名 ]:
Delphinidin chloride

[中文别名 ]:

[英文别名 ]:

T66 BOJ CR CQ DQ DQ& GQ IQ &&Chloride
Delphinidin chloride

氯化飞燕草素生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

信号通路 >> 干细胞及 Wnt 通路 >> STAT

研究领域 >> 癌症

研究领域 >> 心血管疾病

信号通路 >> JAK/STAT信号通路 >> JAK

信号通路 >> 表观遗传学 >> JAK

信号通路 >> 干细胞及 Wnt 通路 >> JAK

信号通路 >> JAK/STAT信号通路 >> STAT

[参考文献]

[1]. Nyman NA, et, al. Determination of anthocyanidins in berries and red wine by high-performance liquid chromatography. J Agric Food Chem. 2001 Sep;49(9):4183-7.

[2]. Andriambeloson E, et, al. Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. J Nutr. 1998 Dec;128(12):2324-33.

[3]. Zhang Z, et, al. Delphinidin modulates JAK/STAT3 and MAPKinase signaling to induce apoptosis in HCT116 cells. Environ Toxicol. 2021 May 6.

氯化飞燕草素物理化学性质

[ 密度 ]:
1.3946 (rough estimate)

[ 沸点 ]:
454.94°C (rough estimate)

[ 熔点 ]:
>350ºC

[ 分子式 ]:
C₁₅H₁₁ClO₇

[ 分子量 ]:
338.697

[ 精确质量 ]:
338.019318

[ PSA ]:
134.52000

[ 折射率 ]:
1.4429 (estimate)

[ 储存条件 ]:
−20°C

氯化飞燕草素MSDS

氯化飞燕草素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DK1310000

CHEMICAL NAME :: 1-Benzopyrylium, 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-, chloride

CAS REGISTRY NUMBER :: 528-53-0

LAST UPDATED :: 199512

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H11-O7.Cl

MOLECULAR WEIGHT :: 338.71

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHYREH Phytotherapy Research. (Heyden & Son Ltd., Spectrum House, Hillview Gardens, London, NW4 2JQ, UK) V.1- 1987- Volume(issue)/page/year: 6,99,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4229439

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHYREH Phytotherapy Research. (Heyden & Son Ltd., Spectrum House, Hillview Gardens, London, NW4 2JQ, UK) V.1- 1987- Volume(issue)/page/year: 6,99,1992

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氯化飞燕草素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DK1310000

[ 海关编码 ]:
2907299090

氯化飞燕草素合成路线

氯化飞燕草素海关

[ 海关编码 ]: 2907299090

[ 中文概述 ]:
2907299090 其他多元酚，酚醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

氯化飞燕草素文献

The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites.

Free Radic. Res. 36(11) , 1229-41, (2002)

Berry extracts rich in anthocyanins have been linked to protective effects including the modulation of age-related neurological dysfunction and the improvement of the resistance of red blood cells aga...

Transcriptome sequencing and metabolite analysis reveals the role of delphinidin metabolism in flower colour in grape hyacinth.

J. Exp. Bot. 65(12) , 3157-64, (2014)

Grape hyacinth (Muscari) is an important ornamental bulbous plant with an extraordinary blue colour. Muscari armeniacum, whose flowers can be naturally white, provides an opportunity to unravel the co...

Functional characterization of an anthocyanidin reductase gene from the fibers of upland cotton (Gossypium hirsutum).

Planta 241(5) , 1075-89, (2015)

Metabolic profiling, gene cloning, enzymatic analysis, ectopic expression, and gene silencing experiments demonstrate that the anthocyanidin reductase (ANR) pathway is involved in the biosynthesis of ...

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