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3,4,5-三甲氧基苯甲酸(8-二乙氨基正辛基)酯盐酸盐

用途

TMB-8 是一种新型 Ca 2+拮抗剂。TMB-8 可能通过阻断细胞内结合储备的Ca 2+释放,从而在平滑肌中产生抑制作用。

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名称

[ CAS 号 ]:
53464-72-5

[ 中文名 ]:
3,4,5-三甲氧基苯甲酸(8-二乙氨基正辛基)酯盐酸盐

[ 英文名 ]:
TMB-8

[中文别名 ]:

[英文别名 ]:

MFCD00012502
EINECS 258-574-5

生物活性

[ 描述 ]:

TMB-8 是一种新型 Ca 2+拮抗剂。TMB-8 可能通过阻断细胞内结合储备的Ca 2+释放,从而在平滑肌中产生抑制作用。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

研究领域 >> 神经疾病

[参考文献]

[1]. Malagodi MH, et al. Pharmacological evaluation of a new Ca2+ antagonist, 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8): studies in smooth muscles. Eur J Pharmacol. 1974 Jun;27(1):25-33.

物理化学性质

[ 密度 ]:
1.018g/cm3

[ 沸点 ]:
461.2ºC at 760mmHg

[ 熔点 ]:
94-97 °C(lit.)

[ 分子式 ]:
C₂₂H₃₈ClNO₅

[ 分子量 ]:
431.99

[ 闪点 ]:
232.8ºC

[ 精确质量 ]:
431.24400

[ PSA ]:
57.23000

[ LogP ]:
5.35360

[ 储存条件 ]:
-20°C Freezer

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2922509090

海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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