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左旋多巴D3

左旋多巴D3用途

左旋多巴-2,5,6-d3(左旋多巴-2,5,6-d3)是氘标记的左旋多巴。左旋多巴(左旋多巴)是神经递质多巴胺的口服活性代谢前体。左旋多巴能穿过血脑屏障,在大脑中转化为多巴胺[1][2][3]。

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左旋多巴D3名称

[ CAS 号 ]:
53587-29-4

[ 中文名 ]:
3-(3,4-二羟基苯基-2,5,6-d3)-L-丙氨酸

[ 英文名 ]:
3-Hydroxy-L-(2,5,6-2H3)tyrosine

[英文别名 ]:

L-DOPA-2,5,6-d3
L-Tyrosine-2,5,6-d, 3-hydroxy-
Dopa-phenyl-d3
MFCD00075014
L-Dihydroxyphenylalanine-2H3
3-Hydroxy-L-(2,5,6-H)tyrosine
2,3,6-trideuterio-4,5-dihydroxy-phenylalanine

左旋多巴D3生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[体外研究]

氢、碳和其他元素的稳定重同位素已被纳入药物分子,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Hyland K, et al. Aromatic L-amino acid decarboxylase deficiency: diagnostic methodology. Clin Chem. 1992 Dec;38(12):2405-10.

[3]. Merims D, et al. Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease. Parkinsonism Relat Disord. 2008;14(4):273-80. Epub 2007 Nov 7.

[4]. Perez-Pardo P, et al. Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson's Disease. Front Aging Neurosci. 2018 Aug 3;10:237.

[5]. Park HJ, et al. Anti-allodynic effects of levodopa in neuropathic rats. Yonsei Med J. 2013 Mar 1;54(2):330-5.

左旋多巴D3物理化学性质

[ 密度 ]:
1.49g/cm3

[ 沸点 ]:
448.4ºC at 760 mmHg

[ 熔点 ]:
292ºC (dec.)(lit.)

[ 分子式 ]:
C₉H₈D₃NO₄

[ 分子量 ]:
200.20600

[ 闪点 ]:
225ºC

[ 精确质量 ]:
200.08800

[ PSA ]:
103.78000

[ LogP ]:
0.75250

[ 外观性状 ]:
白色至灰白色固体

[ 折射率 ]:
1.654

[ 储存条件 ]:
-20°C，存于惰性气体中

左旋多巴D3安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

左旋多巴D3文献

Restriction of dopamine signaling to the dorsolateral striatum is sufficient for many cognitive behaviors.

Proc. Natl. Acad. Sci. U. S. A. 106(34) , 14664-9, (2009)

The striatum is a vital substrate for performance, procedural memory, and learning. The ventral and medial striatum are thought to be critical for acquisition of tasks while the dorsolateral striatum ...

Capsules from pathogenic and non-pathogenic Cryptococcus spp. manifest significant differences in structure and ability to protect against phagocytic cells.

PLoS ONE 7 , e29561, (2012)

Capsule production is common among bacterial species, but relatively rare in eukaryotic microorganisms. Members of the fungal Cryptococcus genus are known to produce capsules, which are major determin...

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