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4-异丙基苯甲酸

4-异丙基苯甲酸用途

4-异丙基苯甲酸是一种芳香族单萜类化合物,是从白屈菜茎皮中分离得到的。4-异丙基苯甲酸具有抗真菌活性。4-异丙基苯甲酸也是蘑菇酪氨酸酶的可逆和非竞争性抑制剂[1][2]。

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4-异丙基苯甲酸名称

[ CAS 号 ]:
536-66-3

[ 中文名 ]:
4-异丙基苯甲酸

[ 英文名 ]:
4-Isopropylbenzoic acid

[中文别名 ]:

[英文别名 ]:

p-cumic acid
EINECS 208-642-5
cumic acid
Benzoic acid, 4-(1-methylethyl)-
4-propan-2-ylbenzoic acid
4-Isopropylbenzoic acid
p-Isopropylbenzoic acid
CuMinic Acid
MFCD00002564

4-异丙基苯甲酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[参考文献]

[1]. Jayasinghe L, et, al. Antifungal constituents of the stem bark of Bridelia retusa. Phytochemistry. 2003 Feb;62(4):637-41.

[2]. Huang XH, et, al. Inhibition of the activity of mushroom tyrosinase by alkylbenzoic acids. Food Chemistry. 2006 Jan; 94(1): 1-6.

4-异丙基苯甲酸物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
271.8±19.0 °C at 760 mmHg

[ 熔点 ]:
117-120 °C(lit.)

[ 分子式 ]:
C₁₀H₁₂O₂

[ 分子量 ]:
164.201

[ 闪点 ]:
128.1±16.2 °C

[ 精确质量 ]:
164.083725

[ PSA ]:
37.30000

[ LogP ]:
3.23

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.535

[ 储存条件 ]:
室温

[ 水溶解性 ]:
sparingly soluble

4-异丙基苯甲酸MSDS

详细MSDS(安全技术说明书)

4-异丙基苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH3850500

CHEMICAL NAME :: Benzoic acid, 4-(1-methylethyl)-

CAS REGISTRY NUMBER :: 536-66-3

BEILSTEIN REFERENCE NO. :: 1907514

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H12-O2

MOLECULAR WEIGHT :: 164.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,215,1954

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4-异丙基苯甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20/21/22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DH3850500

[ 海关编码 ]:
2916399090

4-异丙基苯甲酸上下游产品

4-异丙基苯甲酸上游产品

4-异丙基苯甲酸下游产品

4-异丙基苯甲酸海关

[ 海关编码 ]: 2916399090

[ 中文概述 ]:
2916399090 其他芳香一元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

4-异丙基苯甲酸文献

3D-QSAR and molecular docking studies of benzaldehyde thiosemicarbazone, benzaldehyde, benzoic acid, and their derivatives as phenoloxidase inhibitors.

Bioorg. Med. Chem. 15 , 2006-15, (2007)

Phenoloxidase (PO), also known as tyrosinase, is a key enzyme in insect development, responsible for catalyzing the hydroxylation of tyrosine into o-diphenols and the oxidation of o-diphenols into o-q...

Anaerobic activation of p-cymene in denitrifying betaproteobacteria: methyl group hydroxylation versus addition to fumarate.

Appl. Environ. Microbiol. 80(24) , 7592-603, (2014)

The betaproteobacteria "Aromatoleum aromaticum" pCyN1 and "Thauera" sp. strain pCyN2 anaerobically degrade the plant-derived aromatic hydrocarbon p-cymene (4-isopropyltoluene) under nitrate-reducing c...

Bacterial metabolism of side chain fluorinated aromatics: cometabolism of 4-trifluoromethyl(TFM)-benzoate by 4-isopropylbenzoate grown Pseudomonas putida JT strains.

Arch. Microbiol. 149(3) , 198-206, (1988)

Enzymes of the p-cymene pathway in Pseudomonas putida strains cometabolized the intermediate analogue 4-trifluoromethyl(TFM)benzoate. Three products, 4-TFM-2,3-dihydro-2,3-dihydroxybenzoate, 4-TFM-2,3...

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