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N-(2-氯乙基)二苄胺盐酸盐

N-(2-氯乙基)二苄胺盐酸盐用途

Dibenamine hydrochloride 是一种竞争和不可逆的肾上腺素能 (b>adrenergic) 阻断剂,可以修饰肾上腺素的药理作用。Dibenamine hydrochloride 对小鼠体内肾上腺素的破坏率显著增加。

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N-(2-氯乙基)二苄胺盐酸盐名称

[ CAS 号 ]:
55-43-6

[ 中文名 ]:
N-(2-氯乙基)二苄胺盐酸盐

[ 英文名 ]:
Dibenamine hydrochloride

[中文别名 ]:

[英文别名 ]:

N,N-dibenzyl-2-chloroethanamine,hydrochloride
MFCD00012518
EINECS 200-234-5

N-(2-氯乙基)二苄胺盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 代谢疾病

[ 靶点 ]

IC50: Adrenergic receptor[1]

[体外研究]

二烯胺(100nm-10μM)可减弱可卡因引起的豚鼠离体输精管对乙酰胆碱敏感性增加的程度,但对乙酰胆碱收缩无任何影响。此外,二苯胺诱导的抑制程度依赖于二苯胺的浓度,与可卡因的浓度成反比[3]。

[体内研究]

盐酸二烯胺(皮下注射；25 mg/kg；给药前48和24小时)可使CHCl3水平在2小时和6小时降低30-50%,但对CHCl3的半衰期没有明显影响肝脏。预处理二苯胺明显减缓了四氯化碳转化为三氯甲烷的速度[1]。

[参考文献]

[1]. R W SCHAYER, et al. Effect of dibenamine (N-(2-chloroethyl) dibenzylamine) on the metabolism of radioactive epinephrine.J Biol Chem. 1953 May;202(1):39-43.

[2]. H M Maling,et al. Nature of the protection against carbon tetrachloride-induced hepatotoxicity produced by pretreatment with dibenamine (N-(2-chloroethyl)dibenzylamine). Biochem Pharmacol. 1974 May 15;23(10):1479-91.

[3]. K Araki, et al. Pharmacological studies on supersensitization. VII. Inhibitory effect of dibenamine on cocaine-induced supersensitivity of isolated vas deferens of guinea pig. J Pharmacobiodyn. 1982 Oct;5(10):789-95.

N-(2-氯乙基)二苄胺盐酸盐物理化学性质

[ 密度 ]:
1.107g/cm3

[ 沸点 ]:
320ºC at 760mmHg

[ 熔点 ]:
190-193 °C(lit.)

[ 分子式 ]:
C₁₆H₁₉Cl₂N

[ 分子量 ]:
296.23500

[ 闪点 ]:
147.3ºC

[ 精确质量 ]:
295.08900

[ PSA ]:
3.24000

[ LogP ]:
4.72960

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 储存条件 ]:
室温

N-(2-氯乙基)二苄胺盐酸盐MSDS

详细MSDS(安全技术说明书)

N-(2-氯乙基)二苄胺盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HQ6825000

CHEMICAL NAME :: Dibenzylamine, N-(2-chloroethyl)-, hydrochloride

CAS REGISTRY NUMBER :: 55-43-6

LAST UPDATED :: 199706

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H18-Cl-N.Cl-H

MOLECULAR WEIGHT :: 296.26

WISWESSER LINE NOTATION :: G2N1R&1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from small intestine

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,167,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from small intestine

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,167,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,167,1947

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,167,1947

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N-(2-氯乙基)二苄胺盐酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
HQ6825000

[ 海关编码 ]:
2921499090

N-(2-氯乙基)二苄胺盐酸盐上下游产品

N-(2-氯乙基)二苄胺盐酸盐上游产品

N-(2-氯乙基)二苄胺盐酸盐下游产品

N-(2-氯乙基)二苄胺盐酸盐海关

[ 海关编码 ]: 2921499090

[ 中文概述 ]:
2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

N-(2-氯乙基)二苄胺盐酸盐文献

Nature of the protection against carbon tetrachloride-induced hepatotoxicity produced by pretreatment with dibenamine (N-(2-chloroethyl)dibenzylamine).

Biochem. Pharmacol. 23(10) , 1479-91, (1974)

Effect of dibenamine (N-(2-chloroethyl) dibenzylamine) on the metabolism of radioactive epinephrine.

J. Biol. Chem. 202(1) , 39-43, (1953)

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