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6-(马来酰亚胺基)己酸琥珀酰亚胺酯

6-(马来酰亚胺基)己酸琥珀酰亚胺酯用途

6-Maleimidohexanoic acid N-hydroxysuccinimide ester(ECMS)是抗体偶联药物(ADC)中常用保护基团。

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6-(马来酰亚胺基)己酸琥珀酰亚胺酯名称

[ CAS 号 ]:
55750-63-5

[ 中文名 ]:
6-(马来酰亚胺基)己酸琥珀酰亚胺酯

[ 英文名 ]:
N-Succinimidyl 6-maleimidohexanoate

[中文别名 ]:

[英文别名 ]:

MFCD00043043
N-succinimidyl-6-maleimidocaproate
MCOSU
EMCS

6-(马来酰亚胺基)己酸琥珀酰亚胺酯生物活性

[ 描述 ]:

6-Maleimidohexanoic acid N-hydroxysuccinimide ester(ECMS)是抗体偶联药物(ADC)中常用保护基团。

[ 相关类别 ]:

信号通路 >> 抗体- 药物偶联物 >> ADC连接器

研究领域 >> 癌症

[相关活性小分子]

6-(马来酰亚胺基)己酸琥珀酰亚胺酯物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
480.6±47.0 °C at 760 mmHg

[ 熔点 ]:
70-73 °C(lit.)

[ 分子式 ]:
C₁₄H₁₆N₂O₆

[ 分子量 ]:
308.287

[ 闪点 ]:
244.5±29.3 °C

[ 精确质量 ]:
308.100830

[ PSA ]:
101.06000

[ LogP ]:
-0.81

[ 外观性状 ]:
白色至奶油色色的晶体

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.577

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
chloroform: 100mg/mL

6-(马来酰亚胺基)己酸琥珀酰亚胺酯MSDS

6-(马来酰亚胺基)己酸琥珀酰亚胺酯安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335-H351

[ 警示性声明 ]:
P280-P305 + P351 + P338-P337 + P313

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2925190090

6-(马来酰亚胺基)己酸琥珀酰亚胺酯合成路线

6-(马来酰亚胺基)己酸琥珀酰亚胺酯上下游产品

6-(马来酰亚胺基)己酸琥珀酰亚胺酯上游产品

6-(马来酰亚胺基)己酸琥珀酰亚胺酯下游产品

6-(马来酰亚胺基)己酸琥珀酰亚胺酯海关

[ 海关编码 ]: 2925190090

[ 中文概述 ]:
2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

6-(马来酰亚胺基)己酸琥珀酰亚胺酯文献

Function of the Histone-Like Protein H-NS in Motility of Escherichia coli: Multiple Regulatory Roles Rather than Direct Action at the Flagellar Motor.

J. Bacteriol. 197 , 3110-20, (2015)

A number of investigations of Escherichia coli have suggested that the DNA-binding protein H-NS, in addition to its well-known functions in chromosome organization and gene regulation, interacts direc...

Successful acquisition of a neutralizing monoclonal antibody against a novel neutrophil-activating peptide, mitocryptide-1.

Biochem. Biophys. Res. Commun. 463 , 54-9, (2015)

Mitocryptide-1 (MCT-1) is a novel neutrophil-activating peptide derived from mitochondrial cytochrome c oxidase subunit VIII, and its physiological role and involvement in various diseases have not ye...

Moderate PEGylation of the carrier protein improves the polysaccharide-specific immunogenicity of meningococcal group A polysaccharide conjugate vaccine.

Vaccine 33 , 3208-14, (2015)

Neisseria meningitidis can cause severe and fulminant diseases such as meningitis. Meningococcal capsular polysaccharide (PS) is a key virulence determinant that is not able to induce immunological me...

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