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4-硝基喹啉-N-氧化物

4-硝基喹啉-N-氧化物用途

硝基钦(4-NQO)是一种化学致癌物。Nitrochin在食管细胞中诱导肿瘤抑制素-M(OSM)。Nitrochin诱导DNA损伤,并通过p53依赖性线粒体信号通路诱导细胞凋亡[1][2]。

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4-硝基喹啉-N-氧化物名称

[ CAS 号 ]:
56-57-5

[ 中文名 ]:
4-硝基喹啉-N-氧化物

[ 英文名 ]:
4-Nitroquinoline 1-oxide

[中文别名 ]:

[英文别名 ]:

EINECS 200-281-1
MFCD00006738
4-nitro-1-oxidoquinolin-1-ium
4-nitroquinoline-N-oxide
Quinoline, 4-nitro-, 1-oxide
4-Nitroquinoline 1-oxide
4-nitroquinoline n-oxide

4-硝基喹啉-N-氧化物生物活性

[ 描述 ]:

硝基钦(4-NQO)是一种化学致癌物。Nitrochin在食管细胞中诱导肿瘤抑制素-M(OSM)。Nitrochin诱导DNA损伤,并通过p53依赖性线粒体信号通路诱导细胞凋亡[1][2]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[参考文献]

[1]. Mukherjee A, et al. Carcinogen 4-Nitroquinoline Oxide (4-NQO) Induces Oncostatin-M (OSM) in Esophageal Cells. In Vivo. 2023 Mar-Apr;37(2):506-518.

[2]. Han H, et al. 4-NQO induces apoptosis via p53-dependent mitochondrial signaling pathway. Toxicology. 2007 Feb 12;230(2-3):151-63.

4-硝基喹啉-N-氧化物物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
387.6±34.0 °C at 760 mmHg

[ 熔点 ]:
154-156 °C(lit.)

[ 分子式 ]:
C₉H₆N₂O₃

[ 分子量 ]:
190.16

[ 闪点 ]:
188.2±25.7 °C

[ 精确质量 ]:
190.037842

[ PSA ]:
71.28000

[ LogP ]:
0.92

[ 外观性状 ]:
黄色-棕色晶体或粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.659

[ 储存条件 ]:
−20°C

[ 稳定性 ]:
Stable. Hygroscopic, light-sensitive. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
acetone: clear to hazy

4-硝基喹啉-N-氧化物MSDS

详细MSDS(安全技术说明书)

4-硝基喹啉-N-氧化物安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H350

[ 警示性声明 ]:
P201-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R33

[ 安全声明 (欧洲) ]:
S53-S45

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
3

[ RTECS号 ]:
VC2100000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

4-硝基喹啉-N-氧化物上下游产品

4-硝基喹啉-N-氧化物上游产品

4-硝基喹啉-N-氧化物下游产品

4-硝基喹啉-N-氧化物制备

用硫酸与硝酸硝化喹啉-N-氧化物制得。

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4-硝基喹啉-N-氧化物文献

Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.

J. Mol. Biol. 426(24) , 4049-60, (2014)

Rad23 was identified as a DNA repair protein, although a role in protein degradation has been described. The protein degradation function of Rad23 contributes to cell cycle progression, stress respons...

DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis.

J. Cell Biol. 206(2) , 183-97, (2014)

Deoxyribonucleic acid (DNA) lesions encountered during replication are often bypassed using DNA damage tolerance (DDT) pathways to avoid prolonged fork stalling and allow for completion of DNA replica...

Genotoxicity testing of esterified propoxylated glycerol (EPG).

Regul Toxicol Pharmacol 70 Suppl 2 , S131-42, (2014)

Four versions of esterified propoxylated glycerols (EPGs) were evaluated for potential genotoxicity using a range of in vitro and in vivo assays. H-EPG-05 HR/SO 9:1, H-EPG-05 soyate, and H-EPG-14 soya...

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