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地美溴铵

地美溴铵用途

Demecarium Bromide (BC-48) 是一种有效的 cholinesterase 抑制剂,Kiapp 值为 0.15 μM。Demecarium Bromide (BC-48) 用作青光眼治疗剂。

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地美溴铵名称

[ CAS 号 ]:
56-94-0

[ 中文名 ]:
地美溴铵

[ 英文名 ]:
Demecarium bromide

[中文别名 ]:

[英文别名 ]:

Tosmilen
Visumiotic
Demekastigmine bromide
Tonilen
Humorsol
Tosmicil
Tosmilene
EINECS 200-301-9
Demecarium bromide
Frumtosnil

地美溴铵生物活性

[ 描述 ]:

Demecarium Bromide (BC-48) 是一种有效的 cholinesterase 抑制剂,Kiapp 值为 0.15 μM。Demecarium Bromide (BC-48) 用作青光眼治疗剂。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> 疼痛

[ 靶点 ]

Kiapp: 0.15 μM (Cholinesterase)[1]

[体内研究]

去甲肾上腺素(0.125和0.5％)引起长期瞳孔缩小,降低了正常血压眼和遗传性青光眼的小于眼内压(IOP)[1]。

[参考文献]

[1]. Brown JH, et al. Activation and blockade of cardiac muscarinic receptors by endogenous acetylcholine and cholinesterase inhibitors. J Pharmacol Exp Ther. 1982 Oct;223(1):20-4.

[2]. Gum GG, et al. Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma. Am J Vet Res. 1993 Feb;54(2):287-93.

地美溴铵物理化学性质

[ 熔点 ]:
164 - 170ºC

[ 分子式 ]:
C₃₂H₅₂Br₂N₄O₄

[ 分子量 ]:
716.588

[ 精确质量 ]:
714.235535

[ PSA ]:
59.08000

[ LogP ]:
0.77020

[ 储存条件 ]:
2-8℃

地美溴铵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BR3130000

CHEMICAL NAME :: Ammonium, (m-hydroxyphenyl)trimethyl-, bromide, decamethylenebis(methylcarbamate)

CAS REGISTRY NUMBER :: 56-94-0

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C32-H52-N4-O4.2Br

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6490 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,168,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 29 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 128,307,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,168,1967 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3186 No. of Facilities: 9 (estimated) No. of Industries: 2 No. of Occupations: 9 No. of Employees: 3239 (estimated) No. of Female Employees: 1168 (estimated)

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地美溴铵安全信息

[ 安全声明 (欧洲) ]:
S22-S26-S36/37-S36/37/39

[ 危险品运输编码 ]:
3077

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
9