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醋酸氯己定

醋酸氯己定用途

Chlorhexidine diacetate 是一种双胍类杀菌剂,对革兰氏阳性菌和革兰氏阴性菌均有快速杀菌作用。Chlorhexidine diacetate 的抗菌作用与其对细菌细胞膜的作用和细胞内物质的沉淀有关。

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醋酸氯己定名称

[ CAS 号 ]:
56-95-1

[ 中文名 ]:
醋酸氯己定

[ 英文名 ]:
Chlorhexidine diacetate

[中文别名 ]:

[英文别名 ]:

CHLORASEPT 2000
UNII-5908ZUF22Y
EINECS 200-302-4
Chlorhexidine acetate
MFCD00012532
chlorzoin

醋酸氯己定生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Sanchez IR, et al. Chlorhexidine diacetate and povidone-iodine cytotoxicity to canine embryonic fibroblasts and Staphylococcus aureus. Vet Surg. 1988;17(4):182-185.

醋酸氯己定物理化学性质

[ 沸点 ]:
699.3ºC at 760mmHg

[ 熔点 ]:
153-156ºC

[ 分子式 ]:
C₂₆H₃₈Cl₂N₁₀O₄

[ 分子量 ]:
625.55

[ 闪点 ]:
376.7ºC

[ PSA ]:
204.88000

[ LogP ]:
6.37470

[ 外观性状 ]:
白色至淡黄色粉末

[ 储存条件 ]:
库房低温通风干燥

[ 水溶解性 ]:
H2O: 15 mg/mL, clear | 1.9 g/100 mL (20 ºC)

醋酸氯己定MSDS

详细MSDS(安全技术说明书)

醋酸氯己定毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU1930000

CHEMICAL NAME :: Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-, diacetate

CAS REGISTRY NUMBER :: 56-95-1

LAST UPDATED :: 199504

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C22-H30-Cl2-N10.2C2-H4-O2

MOLECULAR WEIGHT :: 625.64

WISWESSER LINE NOTATION :: GR DMYUM&MYUM&M6MYUM&MYUM&MR DG &QV1 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(6),309,1985 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 9,192,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 38 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 9,192,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 325 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 9,192,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 9,192,1954 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81769 No. of Facilities: 232 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1737 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81769 No. of Facilities: 76 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1050 (estimated) No. of Female Employees: 727 (estimated)

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醋酸氯己定安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H410

[ 警示性声明 ]:
P273-P301 + P312 + P330-P391-P501

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R43

[ 安全声明 (欧洲) ]:
S36/37

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ WGK德国 ]:
3

[ RTECS号 ]:
DU1930000

醋酸氯己定上下游产品

醋酸氯己定上游产品

醋酸氯己定下游产品

醋酸氯己定制备

由对氯苯胺经重氮化，缩合、消除脱氮、缩合、中和成盐制得。

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醋酸氯己定文献

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醋酸氯己定

醋酸氯己定用途

醋酸氯己定名称

醋酸氯己定生物活性

醋酸氯己定物理化学性质

醋酸氯己定MSDS

详细MSDS(安全技术说明书)

醋酸氯己定毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

醋酸氯己定安全信息

醋酸氯己定上下游产品

醋酸氯己定上游产品

醋酸氯己定下游产品

醋酸氯己定制备

醋酸氯己定文献

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