< 生产厂家价格 >

氯己定

氯己定用途

Chlorhexidine是一种抗菌剂, 用作防腐剂和其他用途。

点击显示

氯己定名称

[ CAS 号 ]:
55-56-1

[ 中文名 ]:
氯己定

[ 英文名 ]:
Chlorhexidine

[中文别名 ]:

[英文别名 ]:

Clorhexidina
Tubulicid
Peridex
chlorohexidine
Chlorhexidinum
Rotersept
EINECS 200-238-7
Chlorhexidine base
Chlorhexidin
Sterilon

氯己定生物活性

[ 描述 ]:

Chlorhexidine是一种抗菌剂, 用作防腐剂和其他用途。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

氯己定物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
591.7±60.0 °C at 760 mmHg

[ 熔点 ]:
134-136 °C(lit.)

[ 分子式 ]:
C₂₂H₃₀Cl₂N₁₀

[ 分子量 ]:
505.447

[ 闪点 ]:
311.6±32.9 °C

[ 精确质量 ]:
504.203186

[ PSA ]:
167.58000

[ LogP ]:
4.58

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.659

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
0.08 g/100 mL (20 ºC)

氯己定MSDS

详细MSDS(安全技术说明书)

氯己定毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU1925000

CHEMICAL NAME :: Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-

CAS REGISTRY NUMBER :: 55-56-1

BEILSTEIN REFERENCE NO. :: 2826432

LAST UPDATED :: 199710

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C22-H30-Cl2-N10

MOLECULAR WEIGHT :: 505.52

WISWESSER LINE NOTATION :: GR DMYUM&MYUM&M6MYUM&MYUM&MR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9200 uL/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - other changes Gastrointestinal - ulceration or bleeding from stomach

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2515 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 44 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 632 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >8 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 uL/kg/30D-I

TOXIC EFFECTS :: Blood - changes in leukocyte (WBC) count Biochemical - Metabolism (Intermediary) - lipids including transport Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1680 mg/kg

SEX/DURATION :: female 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 7 umol/disc

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 28,249,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84812 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 32 (estimated) No. of Female Employees: 32 (estimated)

点击显示

氯己定安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H319-H334-H335-H410

[ 警示性声明 ]:
P261-P273-P305 + P351 + P338-P342 + P311-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38;R51/53

[ 安全声明 (欧洲) ]:
S26-S36/37-S60-S61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
DU1925000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

氯己定上下游产品

氯己定上游产品

氯己定下游产品

氯己定文献

The role of matrix metalloproteinases and cysteine-cathepsins on the progression of dentine erosion.

Arch. Oral Biol. 60 , 1340-5, (2015)

To evaluate in vitro the effect of the inhibition of endogenous dentinal enzymes (matrix metalloproteinases-MMPs and cysteine cathepsins-CCs) on dentine erosion.Dentine blocks (4mm×4mm×2mm) from sound...

Evaluation of preventive programs in high caries active preschool children.

Swed. Dent. J. 37(1) , 23-9, (2013)

Although caries prevalence in preschool children has dramatically decreased during the last decades it is still a large problem for a minor group of these children. Great efforts have been invested in...

The EpiOcular Eye Irritation Test (EIT) for hazard identification and labelling of eye irritating chemicals: protocol optimisation for solid materials and the results after extended shipment.

Altern. Lab. Anim. 43 , 101-27, (2015)

The 7th Amendment to the EU Cosmetics Directive and the EU REACH Regulation have reinforced the need for in vitro ocular test methods. Validated in vitro ocular toxicity tests that can predict the hum...

更多文献

氯己定