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18-羟基皮质甾酮

18-羟基皮质甾酮用途

18-Hydroxycorticosterone是皮质类固醇和皮质酮的衍生物,可能会引起严重的电解质失衡。

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18-羟基皮质甾酮名称

[ CAS 号 ]:
561-65-9

[ 中文名 ]:
18 Hydroxycorticosterone

[ 英文名 ]:
18-Hydroxycorticosterone

[英文别名 ]:

18-Hydroxy Corticosterone
EINECS 209-221-9
11beta,18,21-Trihydroxypregn-4-ene-3,20-dione

18-羟基皮质甾酮生物活性

[ 描述 ]:

18-Hydroxycorticosterone是皮质类固醇和皮质酮的衍生物,可能会引起严重的电解质失衡。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[相关活性小分子]

18-羟基皮质甾酮物理化学性质

[ 分子式 ]:
C₂₁H₃₀O₅

[ 分子量 ]:
362.46000

[ 闪点 ]:
2 °C - closed cup (lit.)

[ 精确质量 ]:
362.20900

[ PSA ]:
94.83000

[ LogP ]:
1.63910

[ 储存条件 ]:
室温

18-羟基皮质甾酮安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

18-羟基皮质甾酮文献

Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).

J. Med. Chem. 53 , 1712-25, (2010)

Reducing aldosterone action is beneficial in various major diseases such as heart failure. Currently, this is achieved with mineralocorticoid receptor antagonists, however, aldosterone synthase (CYP11...

["High pouch output" syndrome. Role of mineralocorticoid diagnosis after restorative proctocolectomy].

Chirurg. 72(12) , 1446-52, (2001)

The two-phase restorative proctocolectomy is the treatment of choice for surgical therapy of the familial adenomatous polyposis (FAP) and also for the ulcerative colitis (UC). Besides the well-known c...

Dose-dependence of the effects of corticosterone and the non-glucocorticoid, 18-hydroxycorticosterone, on the brush-border Na+/K+ exchanger.

Endocr. Res. 24(3-4) , 601-5, (1998)

Up to now, only glucocorticoids were thought to act on the renal proximal Na+/H+ exchanger. Using fluorimetric techniques we studied the kinetics of Na+/H+ exchange in brush border vesicles from ADX r...

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