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二氢黄体酮

二氢黄体酮用途

5a-Pregnane-3,20-dione 是一种内源性的孕酮代谢物。

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二氢黄体酮名称

[ CAS 号 ]:
566-65-4

[ 中文名 ]:
氢化黄体酮

[ 英文名 ]:
5α-Dihydroprogesterone

[中文别名 ]:

[英文别名 ]:

5a-Dihydroprogesterone
4-07-00-02199 (Beilstein Handbook Reference)
Pregnane-3,20-dione, (5-α)- (9CI)
5alpha-Pregnan-3,20-dione
MFCD00067132
Allopregnane-3,20-dione
UNII:98G4S1OH0Z
5α-pregnane-3,20-dione
(5α)-Pregnane-3,20-dione
Pregnane-3,20-dione

二氢黄体酮生物活性

[ 描述 ]:

5a-Pregnane-3,20-dione 是一种内源性的孕酮代谢物。

[ 相关类别 ]:

研究领域 >> 内分泌

天然产物 >> 黄酮类化合物

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

5a-Pregnane-3,20-dione减少MCF-7乳腺癌细胞中细胞-底物附着,粘附斑块,纽蛋白表达和聚合F-肌动蛋白[1]。

[参考文献]

[1]. Wiebe JP, et al. The endogenous progesterone metabolite, 5a-pregnane-3,20-dione, decreases cell-substrate attachment, adhesion plaques, vinculin expression, and polymerized F-actin in MCF-7 breast cancer cells. Endocrine. 2001 Oct;16(1):7-14.

[相关活性小分子]

二氢黄体酮物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
429.2±38.0 °C at 760 mmHg

[ 熔点 ]:
204 °C

[ 分子式 ]:
C₂₁H₃₂O₂

[ 分子量 ]:
316.478

[ 闪点 ]:
160.3±23.8 °C

[ 精确质量 ]:
316.240234

[ PSA ]:
34.14000

[ LogP ]:
4.31

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.516

[ 储存条件 ]:
室温，密封，干燥

二氢黄体酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4157150

CHEMICAL NAME :: 5-beta-Pregnane-3,20-dione

CAS REGISTRY NUMBER :: 566-65-4

BEILSTEIN REFERENCE NO. :: 2058506

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H32-O2

MOLECULAR WEIGHT :: 316.53

WISWESSER LINE NOTATION :: L E5 B666 OVTJ A1 E1 FV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968

二氢黄体酮

二氢黄体酮用途

二氢黄体酮名称

二氢黄体酮生物活性

二氢黄体酮物理化学性质

二氢黄体酮毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

二氢黄体酮安全信息

二氢黄体酮合成路线

详细合成路线

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二氢黄体酮上游产品

二氢黄体酮下游产品

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