齐美定
齐美定用途
齐美定名称
[ CAS 号 ]:
56775-88-3
[ 中文名 ]:
泽麦定
[ 英文名 ]:
Zimeldine
[中文别名 ]:
[英文别名 ]:
- Normud
- cis-H-102/09
- cis-H 102/09
- Hydrochloride,zimeldine
- H-102/09
- Zimeldine
- Zelmid
- Zimelidine
- cis-Zimelidine
齐美定生物活性
[ 描述 ]:
[ 相关类别 ]:
[体内研究]
[参考文献]
齐美定物理化学性质
[ 密度 ]:
1.3±0.1 g/cm3
[ 沸点 ]:
412.8±45.0 °C at 760 mmHg
[ 分子式 ]:
C16H19BrCl2N2
[ 分子量 ]:
317.224
[ 闪点 ]:
203.4±28.7 °C
[ 精确质量 ]:
316.057495
[ PSA ]:
16.13000
[ LogP ]:
4.63
[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C
[ 折射率 ]:
1.597
齐美定毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UC6555000
- CHEMICAL NAME :
- 2-Propen-1-amine, 3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-, (Z)-
- CAS REGISTRY NUMBER :
- 56775-88-3
- BEILSTEIN REFERENCE NO. :
- 0479680
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C16-H17-Br-N2
- MOLECULAR WEIGHT :
- 317.26
- WISWESSER LINE NOTATION :
- T6NJ CYR DE&U2N1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 56 mg/kg/14D
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - headache Gastrointestinal - nausea or vomiting
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 285,1009,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 900 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic
- REFERENCE :
- DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 24,169,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic
- REFERENCE :
- DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 24,169,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic
- REFERENCE :
- DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 24,169,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic
- REFERENCE :
- DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 24,169,1982 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 280 mg/kg
- SEX/DURATION :
- female 14 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - menstrual cycle changes or disorders
- REFERENCE :
- NEAGDO Neurobiology of Aging. (ANKHO International Inc., POB 426, Fayetteville, NY 13066) V.1- 1980- Volume(issue)/page/year: 7,9,1986
齐美定安全信息
[ 危害码 (欧洲) ]:
Xn
[ 风险声明 (欧洲) ]:
22
[ 安全声明 (欧洲) ]:
S36
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