克拉维酸
克拉维酸用途
克拉维酸名称
[ CAS 号 ]:
58001-44-8
[ 中文名 ]:
克拉维酸
[ 英文名 ]:
Clavulanate
[中文别名 ]:
[英文别名 ]:
- Acide clavulanique
- Acid clavulanico
- acidum clavulanicum
- Clavulansaeure
- EINECS 261-069-2
- CLAVULANIC ACID
- Clavulanate
- Sodium Clavulanate
克拉维酸生物活性
克拉维酸物理化学性质
[ 密度 ]:
1.7±0.1 g/cm3
[ 沸点 ]:
545.8±50.0 °C at 760 mmHg
[ 分子式 ]:
C8H9NO5
[ 分子量 ]:
199.16
[ 闪点 ]:
283.9±30.1 °C
[ 精确质量 ]:
199.048065
[ PSA ]:
87.07000
[ LogP ]:
-1.98
[ 外观性状 ]:
白色至灰白色粉末
[ 蒸汽压 ]:
0.0±3.3 mmHg at 25°C
[ 折射率 ]:
1.644
[ 储存条件 ]:
常温
克拉维酸毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RN6802500
- CHEMICAL NAME :
- 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, (2R-(2-alpha,3Z,5-alpha))-
- CAS REGISTRY NUMBER :
- 58001-44-8
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C8-H9-N-O5
- MOLECULAR WEIGHT :
- 199.18
- WISWESSER LINE NOTATION :
- T45 ANV EOYTJ FU2Q GVQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7936 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,590,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1399 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,590,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1393 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,590,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4526 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,590,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1531 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,590,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2185 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,590,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),129,1980
克拉维酸安全信息
[ 危害码 (欧洲) ]:
Xi
[ 海关编码 ]:
2934995000
克拉维酸合成路线
克拉维酸上下游产品
克拉维酸上游产品
克拉维酸下游产品
克拉维酸制备
方法1:微生物合成,以黄豆粉、葡萄糖、淀粉或糊精为原料,经发酵而成。
方法2:以3-甲硫基丙内酰胺为原料,经烷化、氯化脱羧等步骤反应合成。
克拉维酸海关
[ 海关编码 ]: 2934995000
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克拉维酸相关知识
2022-05-23 18:27:01
克拉维酸(Clavulanate Potassium),商品名棒酸钾。其为氧青霉烷类β-内酰胺酶抑制剂,是由β-内酰胺环和氢化异噁唑环骈合而成的,是一种自杀性的酶抑制剂。 一、临床应用 临床广泛应用克拉维酸钾与青霉素类的复合制剂,如奥格门丁(阿莫西林+克拉维酸钾),替门汀(替卡西林钠+克拉维酸...
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