尼柯霉素 Z

尼柯霉素 Z用途

Nikkomycin Z,一种核苷肽,是一种选择性竞争性几丁质合成 (chitin synthesis) 抑制剂。Nikkomycin Z 具有抗真菌作用,可作为几丁质合酶底物 UDP-N-乙酰氨基葡萄糖的竞争性类似物。
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尼柯霉素 Z名称

[ CAS 号 ]:
59456-70-1

[ 中文名 ]:
华光霉素

[ 英文名 ]:
Nikkomycin Z

[中文别名 ]:

[英文别名 ]:

尼柯霉素 Z生物活性

[ 描述 ]:

Nikkomycin Z,一种核苷肽,是一种选择性竞争性几丁质合成 (chitin synthesis) 抑制剂。Nikkomycin Z 具有抗真菌作用,可作为几丁质合酶底物 UDP-N-乙酰氨基葡萄糖的竞争性类似物。

[ 相关类别 ]:

研究领域 >> 感染
信号通路 >> 抗感染 >> 真菌

[参考文献]

[1]. R Kovács, et al. Synergistic Effect of Nikkomycin Z With Caspofungin and Micafungin Against Candida Albicans and Candida Parapsilosis Biofilms. Lett Appl Microbiol. 2019 Oct;69(4):271-278.

尼柯霉素 Z物理化学性质

[ 密度 ]:
1.646 g/cm3

[ 分子式 ]:
C20H25N5O10

[ 分子量 ]:
495.44000

[ 精确质量 ]:
495.16000

[ PSA ]:
250.32000

[ 折射率 ]:
1.678

[ 储存条件 ]:
2-8°C，密封，干燥

尼柯霉素 Z毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BA2928200
CHEMICAL NAME :
beta-D-Allofuranuronic acid, 5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-met hyl- 1-oxobutyl)amino)-1,5-dideoxy-1-(3,4-dihydro-2,4-diox o-1(2H)-pyrimidinyl)-, (2S-(2R*,3R*,4R*))-
CAS REGISTRY NUMBER :
59456-70-1
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H25-N5-O10
MOLECULAR WEIGHT :
495.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 44,1709,1980
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尼柯霉素 Z安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
BA2928200

尼柯霉素 Z制备

1.由唐德轮枝锭霉菌S-9深层发酵，再经提取制得。工艺流程为：

砂土孢子→茄子瓶菌种→种子罐种子→发酵罐发酵→

板框压滤→滤液浓缩→喷雾干燥→调配→成品
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尼柯霉素 Z文献

SabR enhances nikkomycin production via regulating the transcriptional level of sanG, a pathway-specific regulatory gene in Streptomyces ansochromogenes.

BMC Microbiol. 11 , 164, (2011)

sabR is a pleiotropic regulatory gene which has been shown to positively regulate the nikkomycin biosynthesis and negatively affect the sporulation of Streptomyces ansochromogenes. In this study, we i...

Reshuffling of Aspergillus fumigatus cell wall components chitin and β-glucan under the influence of caspofungin or nikkomycin Z alone or in combination.

Antimicrob. Agents Chemother. 56 , 1595-1598, (2012)

Chitin and β-glucan are major cell wall components of Aspergillus spp. We investigated the antifungal activity of chitin synthesis inhibitors nikkomycin Z, polyoxin D, flufenoxuron, lufenuron, and tef...

Characterization of the PLP-dependent aminotransferase NikK from Streptomyces tendae and its putative role in nikkomycin biosynthesis.

FEBS J. 278(21) , 4122-35, (2011)

As inhibitors of chitin synthase, nikkomycins have attracted interest as potential antibiotics. The biosynthetic pathway to these peptide nucleosides in Streptomyces tendae is only partially known. In...


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