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N-甲硫脲

N-甲硫脲用途

【用途一】
用于有机合成。

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N-甲硫脲名称

[ CAS 号 ]:
598-52-7

[ 中文名 ]:
N-甲基硫脲

[ 英文名 ]:
N-Methylthiourea

[中文别名 ]:

[英文别名 ]:

MFCD00004938
EINECS 209-936-6
Thiourea, N-methyl-
1-Methylthiourea
methylthiourea

N-甲硫脲物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
141.1±23.0 °C at 760 mmHg

[ 熔点 ]:
118-121 °C(lit.)

[ 分子式 ]:
C₂H₆N₂S

[ 分子量 ]:
90.147

[ 闪点 ]:
39.1±22.6 °C

[ 精确质量 ]:
90.025169

[ PSA ]:
70.14000

[ LogP ]:
-0.71

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
6.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.565

[ 储存条件 ]:
2~8°C，密封

[ 水溶解性 ]:
水溶性：可溶；水溶解度：165 g/l 20 °C

N-甲硫脲MSDS

N-甲硫脲毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YT9000000

CHEMICAL NAME :: Urea, 1-methyl-2-thio-

CAS REGISTRY NUMBER :: 598-52-7

LAST UPDATED :: 199709

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C2-H6-N2-S

MOLECULAR WEIGHT :: 90.16

WISWESSER LINE NOTATION :: SUYZM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,260,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 35,409,1980

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 23,335,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2885 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 94,1419,1974 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - gastrointestinal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 23,335,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 200 mg/kg

SEX/DURATION :: female 14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 26(1),19A,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 250 mg/kg

SEX/DURATION :: female 14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 23,335,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 400 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 28,38A,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 gm/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: 49WEAZ "Pesticide Chemistry: Human Welfare and the Environment, Proceedings of the International Congress of Pesticide Chemistry, 5th, Kyoto, Japan, 1982," Miyamoto, J. and Kearney, P.C., eds., Oxford, UK, Pergamon Press Ltd., 1983 Volume(issue)/page/year: 3,479,1983

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N-甲硫脲安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
P264-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
S36/37/39-S45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
YT9000000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2930909090

N-甲硫脲合成路线

N-甲硫脲上下游产品

N-甲硫脲上游产品

N-甲硫脲下游产品

N-甲硫脲制备

一、生产方法简述

在搅拌下将异硫氰酸甲酯滴加到浓氨水中，加毕，加热除去过量的氨。反应混合物经活性炭脱色后，冷却析出甲基硫脲结晶。收率 74%-81% 。

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N-甲硫脲海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-甲硫脲文献

Endothelial nitric oxide synthase deficient mice are protected from lipopolysaccharide induced acute lung injury.

PLoS ONE 10(3) , e0119918, (2015)

Lipopolysaccharide (LPS) derived from the outer membrane of gram-negative bacteria induces acute lung injury (ALI) in mice. This injury is associated with lung edema, inflammation, diffuse alveolar da...

Metabolism of 4-[1-(2-fluoro-4-biphenylyl)ethyl]-2-methylaminothiazole (SM-8849) in rats.

Eur. J. Drug Metab. Pharmacokinet. 22(1) , 25-33, (1997)

Metabolism of 4-[1-(2-fluoro-4-biphenylyl)ethyl]-2-methylaminothiazole (SM-8849), a novel immunomodulatory agent, in rats was investigated. By co-chromatography with authentic samples, desmethylated (...

[Proper use of noxythiolin: an experimental rat study on interaction with lactic acid].

Therapie. 35(3) , 409-12, (1980)

更多文献

N-甲硫脲

N-甲硫脲用途

N-甲硫脲名称

N-甲硫脲物理化学性质

N-甲硫脲MSDS

详细MSDS(安全技术说明书)

N-甲硫脲毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

N-甲硫脲安全信息

N-甲硫脲合成路线

详细合成路线

N-甲硫脲上下游产品

N-甲硫脲上游产品

N-甲硫脲下游产品

N-甲硫脲制备

N-甲硫脲海关

N-甲硫脲文献

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