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甲基脲

甲基脲用途

用于有机合成及制药工业

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甲基脲名称

[ CAS 号 ]:
598-50-5

[ 中文名 ]:
N-甲基脲

[ 英文名 ]:
1-Methylurea

[中文别名 ]:

[英文别名 ]:

EINECS 209-935-0
N-methylthiourea
Monomethylurea
1-Methylurea
Methylmocovina [Czech]
Methyl urea
Methylharnstoff [German]
Methylurea
urea,N-methyl
Urea, N-methyl-

甲基脲物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
114.6±13.0 °C at 760 mmHg

[ 熔点 ]:
~93 °C

[ 分子式 ]:
C₂H₆N₂O

[ 分子量 ]:
74.082

[ 闪点 ]:
23.1±19.8 °C

[ 精确质量 ]:
74.048012

[ PSA ]:
55.12000

[ LogP ]:
-1.23

[ 外观性状 ]:
白色,结晶针状

[ 蒸汽压 ]:
19.8±0.2 mmHg at 25°C

[ 折射率 ]:
1.432

[ 储存条件 ]:
存放于惰性气体之中;避免空气

[ 水溶解性 ]:
1000 g/L (20 ºC)

甲基脲MSDS

甲基脲毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YT7175000

CHEMICAL NAME :: Urea, methyl-

CAS REGISTRY NUMBER :: 598-50-5

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C2-H6-N2-O

MOLECULAR WEIGHT :: 74.10

WISWESSER LINE NOTATION :: ZVM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10189 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Protozoa - Chlamydomonas reinhardi

DOSE/DURATION :: 400 mmol/L

REFERENCE :: FOMIAZ Folia Microbiologica (Prague). (Academia, Vodickova 40, 112 29 Prague 1, Czechoslavakia) V.4- 1959- Volume(issue)/page/year: 20,452,1975

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甲基脲安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22;R37;R68

[ 安全声明 (欧洲) ]:
S22-S36-S45-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YT7175000

[ 海关编码 ]:
29241900

甲基脲合成路线

甲基脲上下游产品

甲基脲上游产品

甲基脲下游产品

甲基脲海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

甲基脲文献

The FGFR Inhibitor NVP-BGJ398 Induces NSCLC Cell Death by Activating Caspase-dependent Pathways as well as Caspase-independent Apoptosis.

Anticancer Res. 35 , 5873-9, (2015)

Fibroblast growth factor receptors are expressed in diverse cell types. They play a critical role in tumor development. Their activation promotes cell-cycle progression, angiogenesis, and cell surviva...

Characteristics of urea transport of cells derived from rabbit thick ascending limb of Henle's loop.

Kidney Int. 54(1) , 152-9, (1998)

The thick ascending limb of Henle's loop (TALH) is thought to be involved in the regulation of the renal urea gradient.We have characterized the uptake of urea (oil density centrifugation and 2-compar...

[Derivatives of antineoplastic antibiotics of the daunorubicin series containing methylurea or nitrosomethylurea residues].

Bioorg. Khim. 16(4) , 559-68, (1990)

Derivatives of antitumour anthracycline antibiotics containing N-methylurea moiety in the carbohydrate ring were obtained by the interaction of methyl isocyanate with daunorubicin, doxorubicin, carmin...

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甲基脲