N-甲硫脲
N-甲硫脲结构式
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常用名 | N-甲硫脲 | 英文名 | N-Methylthiourea |
|---|---|---|---|---|
| CAS号 | 598-52-7 | 分子量 | 90.147 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 141.1±23.0 °C at 760 mmHg | |
| 分子式 | C2H6N2S | 熔点 | 118-121 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 39.1±22.6 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Endothelial nitric oxide synthase deficient mice are protected from lipopolysaccharide induced acute lung injury.
PLoS ONE 10(3) , e0119918, (2015) Lipopolysaccharide (LPS) derived from the outer membrane of gram-negative bacteria induces acute lung injury (ALI) in mice. This injury is associated with lung edema, inflammation, diffuse alveolar damage, and severe respiratory insufficiency. We have previou... |
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Metabolism of 4-[1-(2-fluoro-4-biphenylyl)ethyl]-2-methylaminothiazole (SM-8849) in rats.
Eur. J. Drug Metab. Pharmacokinet. 22(1) , 25-33, (1997) Metabolism of 4-[1-(2-fluoro-4-biphenylyl)ethyl]-2-methylaminothiazole (SM-8849), a novel immunomodulatory agent, in rats was investigated. By co-chromatography with authentic samples, desmethylated (SM-8800) p-hydroxylated (SL-5512) and desmethylated-p-hydro... |
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[Proper use of noxythiolin: an experimental rat study on interaction with lactic acid].
Therapie. 35(3) , 409-12, (1980)
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PPAR-γ regulates carnitine homeostasis and mitochondrial function in a lamb model of increased pulmonary blood flow.
PLoS ONE 7(9) , e41555, (2012) Carnitine homeostasis is disrupted in lambs with endothelial dysfunction secondary to increased pulmonary blood flow (Shunt). Our recent studies have also indicated that the disruption in carnitine homeostasis correlates with a decrease in PPAR-γ expression i... |
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Ameliorative effects of taurine against methimazole-induced cytotoxicity in isolated rat hepatocytes.
Sci. Pharm. 80 , 987-99, (2012) Methimazole is used as an antithyroid drug to control the symptoms of hyperthyroidism and maintain patients in a euthyroid state. Administration of this drug is associated with agranulocytosis and hepatotoxicity, which are the two most significant adverse eff... |
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Role of carnitine acetyl transferase in regulation of nitric oxide signaling in pulmonary arterial endothelial cells.
Int. J. Mol. Sci. 14 , 255-72, (2013) Congenital heart defects with increased pulmonary blood flow (PBF) result in pulmonary endothelial dysfunction that is dependent, at least in part, on decreases in nitric oxide (NO) signaling. Utilizing a lamb model with left-to-right shunting of blood and in... |
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The fate of N-methyl-N'-(hydroxymethyl)thiourea in the rat.
Xenobiotica 13(2) , 73-9, (1983) 1. The fate of N-methyl-N'-(hydroxy[14C]methyl)thiourea (MHT) has been studied in the male Sprague-Dawley rat. The compound is degraded to N-methylthiourea and formaldehyde. 2. N-Methylthiourea is excreted as a urinary metabolite whereas the formaldehyde is n... |
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Evidence for the involvement of N-methylthiourea, a ring cleavage metabolite, in the hepatotoxicity of methimazole in glutathione-depleted mice: structure-toxicity and metabolic studies.
Chem. Res. Toxicol. 13(3) , 170-6, (2000) In mice depleted of GSH by treatment with buthionine sulfoximine (BSO), methimazole (2-mercapto-1-methylimidazole, MMI) causes liver injury characterized by centrilobular necrosis of hepatocytes and an increase in serum alanine transaminase (SALT) activity. M... |
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Decrease in adherence of bacteria and yeasts to human mucosal epithelial cells by noxythiolin in vitro.
J. Appl. Bacteriol. 60(4) , 311-7, (1986) Adherence of buccal and vaginal isolates of Candida albicans to buccal epithelial cells and the adherence of urine isolates of Escherichia coli and Staphylococcus saprophyticus to uroepithelial cells was quantified by light microscopy. The antimicrobial agent... |
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A comparison of the antimicrobial activities of noxythiolin and formaldehyde solutions.
J. Clin. Hosp. Pharm. 10(2) , 185-92, (1985) The availability of a rapid and highly specific polarographic method of analysis for formaldehyde enabled investigation of the rate of formaldehyde release from noxythiolin solutions and actual concentrations of formaldehyde in solutions during clinical use a... |