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2-氯丙酸

2-氯丙酸用途

【用途一】
用于有机合成
【用途二】
用于农药、医药、染料中间体及其他有机合成
【用途三】
α-氯代丙酸是杀菌剂甲霜灵、苯霜灵、恶霜灵,除草剂禾草灵、喹禾灵、吡氟禾草灵、噻唑禾草灵、恶唑禾草灵、氟吡禾灵、乳氟禾草灵和茅草枯、2,4滴丙酸盐、2甲4氯丙酸盐等的中间体。
【用途四】
主要用于生产农药除草剂。2-氯丙酸还用于生产乳酸及有工业价值的低级醇酯。。
【用途五】
用于有机合成及作为除草剂的中间体。
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2-氯丙酸名称

[ CAS 号 ]:
598-78-7

[ 中文名 ]:
2-氯丙酸

[ 英文名 ]:
2-Chloropropanoic acid

[中文别名 ]:

[英文别名 ]:

2-氯丙酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
189.0±13.0 °C at 760 mmHg

[ 熔点 ]:
-12--14 °C

[ 分子式 ]:
C3H5ClO2

[ 分子量 ]:
108.524

[ 闪点 ]:
101.7±0.0 °C

[ 精确质量 ]:
107.997810

[ PSA ]:
37.30000

[ LogP ]:
0.30

[ 外观性状 ]:
无色液体

[ 蒸汽压 ]:
0.3±0.7 mmHg at 25°C

[ 折射率 ]:
1.441

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、碱类分开存放

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong bases.

[ 水溶解性 ]:
freely soluble

2-氯丙酸MSDS

2-氯丙酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UE8575000
CHEMICAL NAME :
Propionic acid, 2-chloro-
CAS REGISTRY NUMBER :
598-78-7
BEILSTEIN REFERENCE NO. :
1720259
LAST UPDATED :
199712
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C3-H5-Cl-O2
MOLECULAR WEIGHT :
108.53
WISWESSER LINE NOTATION :
QVYG1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - hematuria Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555355
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - hematuria Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555355
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
126 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 5,136(89),1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7182 mg/kg/42D-C
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of esophagus Skin and Appendages - hair Related to Chronic Data - changes in testicular weight
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555355 *** REVIEWS *** ACGIH TLV-TWA 0.44 mg/m3 (0.1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 2 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
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2-氯丙酸安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R21/22;R35

[ 安全声明 (欧洲) ]:
S23-S26-S28-S36-S45-S36/37/39-S28A

[ 危险品运输编码 ]:
UN 2511 8/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
UE8575000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
29159080

2-氯丙酸合成路线

2-氯丙酸上下游产品

2-氯丙酸制备

1.由丙酸氯化而得。

2.制法:

于装有搅拌器、温度计、回流冷凝器(连一道气管至氯化氢气吸收装置)、通气导管(伸入瓶底)的反应瓶(预先称重)中,加入丙酸(2)148g(2mol),三氯化磷1.5g,加热至100~110℃,慢慢通入氯气,保持反应℃在105~110℃之间。直至质量增加约70g,大约需要5h。蒸馏,先用水泵减压抽出来未反应的氯气和氯化氢气体,再收集82~85℃/1.6kPa的馏分。得2-氯丙酸(1)160g,收率74.5%。

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2-氯丙酸海关

[ 海关编码 ]: 29159080

2-氯丙酸文献

Haloalkanoate dehalogenase II (DehE) of a Rhizobium sp.--molecular analysis of the gene and formation of carbon monoxide from trihaloacetate by the enzyme.

Eur. J. Biochem. 250(3) , 789-93, (1997)

A 3-kb EcoRI fragment of genomic DNA from a Rhizobium sp. cloned into pUC19 endowed Escherichia coli K-12 with the ability to grow, albeit slowly, with 2-chloropropionic acid as substrate. The constru...

Direct determination of the enantiomeric purity or enantiomeric composition of methylpropionates using a single capacitive microsensor.

Anal. Chem. 81(5) , 1969-75, (2009)

Capacitive enantioselective sensors have been demonstrated to provide antipodal signals upon dosage of, e.g., the enantiomers of methyl lactate or methyl-2-chloropropionate. In a next step, these sens...

Use of structure-activity relationships for probing biochemical mechanisms: glutathione transferase zeta conjugation of haloacids.

Adv. Exp. Med. Biol. 500 , 23-31, (2001)


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公司名:上海化源世纪贸易有限公司

区域:上海市普陀区

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产品详情:2-氯丙酸


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区域:韶关市翁源县

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