2-氯丙酸
2-氯丙酸用途
用于有机合成
【用途二】
用于农药、医药、染料中间体及其他有机合成
【用途三】
α-氯代丙酸是杀菌剂甲霜灵、苯霜灵、恶霜灵,除草剂禾草灵、喹禾灵、吡氟禾草灵、噻唑禾草灵、恶唑禾草灵、氟吡禾灵、乳氟禾草灵和茅草枯、2,4滴丙酸盐、2甲4氯丙酸盐等的中间体。
【用途四】
主要用于生产农药除草剂。2-氯丙酸还用于生产乳酸及有工业价值的低级醇酯。。
【用途五】
用于有机合成及作为除草剂的中间体。
2-氯丙酸名称
[ CAS 号 ]:
598-78-7
[ 中文名 ]:
2-氯丙酸
[ 英文名 ]:
2-Chloropropanoic acid
[中文别名 ]:
[英文别名 ]:
- QVYG1
- 2-Chloropropionicacid
- 2-Chloropropanoic acid
- 2-chloro-propionicaci
- EINECS 209-952-3
- 2-Chloropropionic ac
- Propionic acid, α-chloro-
- RARECHEM AL BO 1240
- 2-chloropropionic
- 2-chloro-propanoicaci
2-氯丙酸物理化学性质
[ 密度 ]:
1.3±0.1 g/cm3
[ 沸点 ]:
189.0±13.0 °C at 760 mmHg
[ 熔点 ]:
-12--14 °C
[ 分子式 ]:
C3H5ClO2
[ 分子量 ]:
108.524
[ 闪点 ]:
101.7±0.0 °C
[ 精确质量 ]:
107.997810
[ PSA ]:
37.30000
[ LogP ]:
0.30
[ 外观性状 ]:
无色液体
[ 蒸汽压 ]:
0.3±0.7 mmHg at 25°C
[ 折射率 ]:
1.441
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、碱类分开存放
[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong bases.
[ 水溶解性 ]:
freely soluble
2-氯丙酸MSDS
2-氯丙酸毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UE8575000
- CHEMICAL NAME :
- Propionic acid, 2-chloro-
- CAS REGISTRY NUMBER :
- 598-78-7
- BEILSTEIN REFERENCE NO. :
- 1720259
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C3-H5-Cl-O2
- MOLECULAR WEIGHT :
- 108.53
- WISWESSER LINE NOTATION :
- QVYG1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - hematuria Skin and Appendages - hair
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555355
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - hematuria Skin and Appendages - hair
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555355
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 126 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 5,136(89),1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7182 mg/kg/42D-C
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of esophagus Skin and Appendages - hair Related to Chronic Data - changes in testicular weight
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555355 *** REVIEWS *** ACGIH TLV-TWA 0.44 mg/m3 (0.1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 2 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
2-氯丙酸安全信息
[ 符号 ]:
GHS05, GHS07
[ 信号词 ]:
Danger
[ 危害声明 ]:
H302-H314
[ 警示性声明 ]:
P280-P305 + P351 + P338-P310
[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
C:Corrosive
[ 风险声明 (欧洲) ]:
R21/22;R35
[ 安全声明 (欧洲) ]:
S23-S26-S28-S36-S45-S36/37/39-S28A
[ 危险品运输编码 ]:
UN 2511 8/PG 3
[ WGK德国 ]:
1
[ RTECS号 ]:
UE8575000
[ 包装等级 ]:
III
[ 危险类别 ]:
8
[ 海关编码 ]:
29159080
2-氯丙酸合成路线
2-氯丙酸上下游产品
2-氯丙酸上游产品
2-氯丙酸下游产品
2-氯丙酸制备
1.由丙酸氯化而得。
2.制法:
于装有搅拌器、温度计、回流冷凝器(连一道气管至氯化氢气吸收装置)、通气导管(伸入瓶底)的反应瓶(预先称重)中,加入丙酸(2)148g(2mol),三氯化磷1.5g,加热至100~110℃,慢慢通入氯气,保持反应℃在105~110℃之间。直至质量增加约70g,大约需要5h。蒸馏,先用水泵减压抽出来未反应的氯气和氯化氢气体,再收集82~85℃/1.6kPa的馏分。得2-氯丙酸(1)160g,收率74.5%。
2-氯丙酸海关
[ 海关编码 ]: 29159080
2-氯丙酸文献
Eur. J. Biochem. 250(3) , 789-93, (1997)
A 3-kb EcoRI fragment of genomic DNA from a Rhizobium sp. cloned into pUC19 endowed Escherichia coli K-12 with the ability to grow, albeit slowly, with 2-chloropropionic acid as substrate. The constru...
Direct determination of the enantiomeric purity or enantiomeric composition of methylpropionates using a single capacitive microsensor.Anal. Chem. 81(5) , 1969-75, (2009)
Capacitive enantioselective sensors have been demonstrated to provide antipodal signals upon dosage of, e.g., the enantiomers of methyl lactate or methyl-2-chloropropionate. In a next step, these sens...
Use of structure-activity relationships for probing biochemical mechanisms: glutathione transferase zeta conjugation of haloacids.Adv. Exp. Med. Biol. 500 , 23-31, (2001)
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