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2’-脱氧尿苷

2’-脱氧尿苷用途

2'-Deoxyuridine 能促使染色体断裂,从而降低 thymidylate 的合成活性,它也是合成 Edoxudine 的一个前体。

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2’-脱氧尿苷名称

[ CAS 号 ]:
951-78-0

[ 中文名 ]:
2'-脱氧尿苷

[ 英文名 ]:
2'-deoxyuridine

[中文别名 ]:

[英文别名 ]:

Uracildeoxyr
deoxyuridine
T6NVMVJ A- ET5OTJ B1Q CQ &&Ribo-β-D Form
2'-deoxy-uridin
1-(2-Deoxy-b-D-erythro-pentofuranosyl)uracil
[131I]-Deoxyuridine
2'-Deoxyuridine
Desoxyuridine
Uridine, 2'-deoxy-
MFCD00006527

2’-脱氧尿苷生物活性

[ 描述 ]:

2'-Deoxyuridine 能促使染色体断裂,从而降低 thymidylate 的合成活性,它也是合成 Edoxudine 的一个前体。

[ 相关类别 ]:

研究领域 >> 感染

天然产物 >> 糖和糖苷

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Reidy JA, et al. Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes. Am J Med Genet. 1987 Jan;26(1):1-5.

[相关活性小分子]

2’-脱氧尿苷物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 熔点 ]:
167-169 °C(lit.)

[ 分子式 ]:
C₉H₁₂N₂O₅

[ 分子量 ]:
228.202

[ 精确质量 ]:
228.074615

[ PSA ]:
104.55000

[ LogP ]:
-1.70

[ 外观性状 ]:
细灰白色结晶粉末

[ 折射率 ]:
1.603

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
300 g/L (20 ºC)

2’-脱氧尿苷MSDS

2’-脱氧尿苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU7490000

CHEMICAL NAME :: Uridine, 2'-deoxy-

CAS REGISTRY NUMBER :: 951-78-0

BEILSTEIN REFERENCE NO. :: 0024433

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H12-N2-O5

MOLECULAR WEIGHT :: 228.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1 mmol/L

REFERENCE :: BICMBE Biochimie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53- 1971- Volume(issue)/page/year: 64,809,1982

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2’-脱氧尿苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YU7490000

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2’-脱氧尿苷文献

Simultaneous quantification of purine and pyrimidine bases, nucleosides and their degradation products in bovine blood plasma by high performance liquid chromatography tandem mass spectrometry.

J. Chromatogr. A. 1356 , 197-210, (2014)

Improved nitrogen utilization in cattle is important in order to secure a sustainable cattle production. As purines and pyrimidines (PP) constitute an appreciable part of rumen nitrogen, an improved u...

Phase I study of oral gemcitabine prodrug (LY2334737) in Japanese patients with advanced solid tumors.

Cancer Chemother. Pharmacol. 71(6) , 1645-55, (2013)

LY2334737 is an oral gemcitabine prodrug. This Phase I study assessed the safety and tolerability of LY2334737 in Japanese patients with solid tumors and evaluated pharmacokinetics (PK), pharmacodynam...

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

J. Med. Chem. 51 , 6740-51, (2008)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared ...

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