光甘草定

光甘草定用途

Glabridin 是从 Glycyrrhiza glabra 中分到的异黄烷类,能够结合并激活 PPARγ,EC50 值为 6115 nM。Glabridin 具有抗氧化、抗菌、抗肾炎、抗糖尿病、抗肿瘤、抗炎、抗骨质疏松、保护心血管、保护神经、清除自由基等作用。

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光甘草定名称

[ CAS 号 ]:
59870-68-7

[ 中文名 ]:
光甘草定

[ 英文名 ]:
Glabridin

[中文别名 ]:

[英文别名 ]:

Glabridin
Bio-0904
BIDD:ER0172
MFCD03427694

光甘草定生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> PPAR

研究领域 >> 炎症/免疫

[ 靶点 ]

PPARγ:6.1 μM (EC50)

[体外研究]

Glabridin结合并激活PPARγ,EC50为6115 nM [1]。 Glabridin(40,80μM)在治疗24和48小时后以剂量和时间依赖性方式抑制SCC-9和SAS细胞系的增殖[2]。 Glabridin(0-80μM)也诱导细胞凋亡,导致SCC-9和SAS细胞系中的亚G1期细胞周期停滞[2]。 Glabridin(0,20,40和80μM)剂量依赖性地激活caspase-3,-8和-9并增加PARP裂解,显着磷酸化SCC-9中的ERK1/2,JNK1/2和p-38 MAPK。细胞[2]。

[体内研究]

Glabridin(50 mg/kg,po每日一次)显示出强效的抗炎活性,改善了葡聚糖硫酸钠(DSS)诱导的大鼠炎症改变[3]。

[参考文献]

[1]. Rebhun JF, et al. Identification of glabridin as a bioactive compound in licorice (Glycyrrhiza glabra L.) extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ). Fitoterapia. 2015 Oct;106:55-61.

[2]. Chen CT, et al. Glabridin induces apoptosis and cell cycle arrest in oral cancer cells through the JNK1/2 signaling pathway. Environ Toxicol. 2018 Jun;33(6):679-685.

[3]. El-Ashmawy NE, et al. Downregulation of iNOS and elevation of cAMP mediate the anti-inflammatory effect of glabridin in rats with ulcerative colitis. Inflammopharmacology. 2018 Apr;26(2):551-559.

光甘草定物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
518.6±50.0 °C at 760 mmHg

[ 熔点 ]:
154-155ºC

[ 分子式 ]:
C₂₀H₂₀O₄

[ 分子量 ]:
324.37

[ 闪点 ]:
267.4±30.1 °C

[ 精确质量 ]:
324.136169

[ PSA ]:
58.92000

[ LogP ]:
4.26

[ 外观性状 ]:
淡黄色粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.623

[ 储存条件 ]:
room temp

光甘草定MSDS

详细MSDS(安全技术说明书)

光甘草定安全信息

[ 危害声明 ]:
H413

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2942000000

光甘草定合成路线

详细合成路线

光甘草定上下游产品

光甘草定上游产品

光甘草定下游产品

光甘草定海关

[ 海关编码 ]: 2942000000

光甘草定文献

Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase 9 through modulation of NF-κB and AP-1 activity in human liver cancer cells.

Br. J. Pharmacol. 171(12) , 3037-50, (2014)

High mortality and morbidity rates for hepatocellular carcinoma in Taiwan primarily result from uncontrolled tumour metastasis. Glabridin, a prenylated isoflavonoid of licorice (Glycyrrhiza glabra) ro...

Novel phytonutrient contributors to antioxidant protection against cardiovascular disease

Nutrition 28(6) , 605-10, (2012)

The associations linking endothelial inflammation, endothelial oxidative stress, and atherogenesis and the potential for dietary phytonutrients to decrease the impact of these associations were assess...

Glabridin inhibits migration, invasion, and angiogenesis of human non-small cell lung cancer A549 cells by inhibiting the FAK/rho signaling pathway.

Integr. Cancer Ther. 10(4) , 341-9, (2011)

This study reports the antimigration, anti-invasive effect of glabridin, a flavonoid obtained from licorice, in human non-small cell lung cancer A549 cells. Glabridin exhibited effective inhibition of...

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